alexa Acute Drug-Induced Hepatitis during Aripiprazole Monotherapy: A Case Report | OMICS International | Abstract
ISSN: 2329-6887

Journal of Pharmacovigilance
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Case Report

Acute Drug-Induced Hepatitis during Aripiprazole Monotherapy: A Case Report

Jürgen Kornischka1, Joachim Cordes2*, Christina Engelke2, Renate Grohmann3 and Marcus Agelink1,4
1Department of Psychiatry, Psychotherapy and Psychosomatic Medicine at the Klinikum Herford, Germany
2Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany
3Department of Psychiatry and Psychotherapy, Ludwig-Maximilian University, Munich, Germany
4Clinic of Psychiatry, Psychotherapy and Preventive Medicine, Ruhr-University of Bochum, Germany
*Corresponding Author : Joachim Cordes
LVR-Klinikum Düsseldorf, Klinik und Poliklinik für
Psychiatrie und Psychotherapie
Heinrich-Heine-Universität Düsseldorf
Bergische Landstr. 2, 40629 Düsseldorf, Germany
Tel: 02119223402
Fax: 02119222020
E-mail: [email protected]
Received: February 26, 2016 Accepted: February 29, 2016 Published: March 07, 2016
Citation: Kornischka J, Cordes J, Engelke C, Grohmann R, Agelink M (2016) Acute Drug-Induced Hepatitis during Aripiprazole Monotherapy: A Case Report. J Pharmacovigil 4:201. doi:10.4172/2329-6887.1000201
Copyright: © 2016 Kornischka J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Only a few case studies have been reported about antipsychotic-induced hepatitis for second generation antipsychotics. A 52-year old patient with recurrent schizoaffective psychosis was switched over from clozapine to aripiprazole monotherapy. Six weeks afterwards the otherwise asymptomatic patient presented herself with skin and scleral jaundice. Hepatic laboratory parameters and liver histological evaluation were initiated. Blood tests performed in outpatient clinic revealed significantly pathological hepatic laboratory parameters (total bilirubin 17.9 mg/dl, direct bilirubin 9.0 mg/dl, GOT 1613 U/l, GPT 2585 U/l). The liver histological evaluation shows a portal inflammatory cellular reaction with eosinophilia. After immediate discontinuation of aripiprazole medication, the elevated laboratory parameters normalised. We assume that the patient had suffered drug-induced hepatitis with predominant cytolysis. This is the first case of aripiprazole-induced hepatitis described in the literature.

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