alexa Acute Generalized Exanthematous Pustulosis in a 51-Year-Old Patient under Etanercept Treatment for Psoriasis
ISSN: 2329-6887

Journal of Pharmacovigilance
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Case Report

Acute Generalized Exanthematous Pustulosis in a 51-Year-Old Patient under Etanercept Treatment for Psoriasis

Luciana Mabel Ferreira Vasconcelos1, Fabricia Martins Teixeira2, Eudiana Vale Francelino3, Thereza Lucia Prata Almeida4,
Larissa Bomfim Chagas4, Jose Telmo Valença Jr5 and Aparecida Tiemi Nagao-Dias6*
1Posgraduation Program of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Ceara (UFC), Brazil
2Central Public Health Laboratory (LACEN), Ceara, Brazil
3Faculty of Pharmacy, Pharmacovigilance Center of Ceara, UFC, Brazil
4Department of Dermatology, Hospital Universitário Walter Cantídio, UFC, Brazil
5Faculty of Medicine, Department of Pathology, UFC, Brazil
6Faculty of Pharmacy, Department of Clinical Analysis and Toxicology, UFC, Brazil
Corresponding Author : Aparecida Tiemi Nagao-Dias
Faculty of Pharmacy, Department of Clinical Analysis and Toxicology
Federal University of Ceara, Rua Capitao Francisco Pedro
1210, CEP 60430-370, Fortaleza, Ceará, Brazil
Tel: 55-85-3366-8270
Fax: 55-85-3366-8292
Received November 06, 2013; Accepted February 04, 2014; Published February 11, 2014
Citation: Vasconcelos LMF, Teixeira FM, Francelino EV, Almeida TLP, Chagas LB, et al. (2014) Acute Generalized Exanthematous Pustulosis in a 51-Year-Old Patient under Etanercept Treatment for Psoriasis. J Pharmacovigilance 2:120. doi: 10.4172/2329-6887.1000120
Copyright: © 2014 Vasconcelos LMF, et al., This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Acute generalized exanthematous pustulosis (AGEP) is a cutaneous reaction mostly related to drug, which is characterized by a rapid appearance of fever, erythema, sterile pustules and neutrophilia. We report a 51-year-old female patient who had taken etanercept 50 mg/week for treatment of psoriasis. In the third month of pharmacotherapy, she interrupted the treatment on her own, and consequently, the lesions reappeared. When the drug was reintroduced, it was associated with prednisone 40 mg/day during 5 days. After this period, multiple erythematous and edematous lesions appeared with small non-follicular pustules. Oral corticosteroid was administered and a progressive and complete improvement was achieved. Histopathological findings revealed AGEP. Bacterioscopy of the pustules proved negative. The patient obtained the score 12 according to the EuroSCAR study group, which indicated a definitive diagnosis of AGEP. The criteria for diagnosis were based on morphology, course and histology of the skin reaction. The association between Etanercept and AGEP is an uncommon finding in the literature.


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