alexa Acute Kidney Injury: New Definitions and Beyond
ISSN: 2161-0959

Journal of Nephrology & Therapeutics
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Review Article

Acute Kidney Injury: New Definitions and Beyond

Abdul-Wahab M. Al-Saqladi*

Department of Pediatrics, Faculty of Medicine and Health Sciences, University of Aden, Yemen

*Corresponding Author:
Dr. Abdul-Wahab M. Al-Saqladi
Department of Pediatrics
Faculty of Medicine and Health Sciences
University of Aden, Yemen
P.O. Box 6032 Khormaksar, Aden, Yemen
Tel: +967(2)384260
E-mail: [email protected]

Received Date: December 16, 2015 Accepted Date: January 09, 2016 Published Date: January 16, 2016

Citation: Al-Saqladi AWM (2016) Acute Kidney Injury: New Definitions and Beyond. J Nephrol Ther 6:234. doi:10.4172/2161-0959.1000234

Copyright: © 2016 Al-Saqladi AWM. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Acute kidney injury (AKI) previously known as acute renal failure is a common clinical syndrome, with multiple etiologies and a complex array of clinical and biochemical changes. AKI affecting all age groups with increasing incidence in hospitalized patients and associated with significant morbidity and mortality. It is until 2004, when the Acute Dialysis Quality Initiative (ADQI) group proposed RIFLE (risk, injury, and failure, loss of function and end-stage renal failure) as consensus criteria for AKI definition and staging. Subsequent refinements and modifications had been proposed to increase specificity and sensitivity of diagnosis and prognosis, including pRIFLE (for children), AKIN and KDIGO. This review focuses on the recent advances in AKI definitions and classifications and highlights area of limitations and controversies.


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