alexa Acute Lymphoblastic Leukemia evolving from atypical Chr
ISSN: 2329-6917

Journal of Leukemia
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Case Report

Acute Lymphoblastic Leukemia evolving from atypical Chronic Myelogenous Leukemia: Case Report and Review of the Literature

Angela Pennisi, Sarah Jewell, Jonathon Gralewski, Daisy Alapat, Bellamy William, Yogesh Jethava and Pooja Motwani*

Division of Hematology and Oncology, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas

*Corresponding Author:
Pooja Motwani
Division of Hematology and Oncology, Winthrop P. Rockefeller Cancer Institute
University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Tel: (501) 526-6990
E-mail: [email protected]

Received date: July 27, 2015; Accepted date: August 17, 2015; Published date: August 27, 2015

Citation: Pennisi A, Jewell S, Gralewski J, Alapat D, William B, et al. (2015) Acute Lymphoblastic Leukemia evolving from atypical Chronic Myelogenous Leukemia: Case Report and Review of the Literature. J Leuk S1:007. doi:10.4172/2329-6917.S1-007

Copyright: © 2015 Pennisi A et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



 

Abstract

Atypical chronic myeloid leukemia (aCML) is a rare chronic myeloproliferative disorder characterized by leukocytosis, absence of Philadelphia chromosome or BCR-ABL rearrangement, and marked myeloid dysplasia. The diagnosis of aCML is difficult and challenging, more so if the initial presentation is with blast crisis. In the absence of characteristic mutational profile, blast crisis of aCML can lead to significant diagnostic dilemma. We describe a case of refractory acute lymphoblastic leukemia (ALL), needing critical evaluation of hemopathological and cytogenetic abnormalities. It was hypothesized that patient had undiagnosed aCML and presented with lymphoid blast crisis. To our knowledge, this is the first described case of aCML presenting with lymphoid blast crisis.

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