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Acute Myeloid Leukemia with t(2;6)(q12;q12) Reveals Dysmegakaryopoietic Finding and Poor Prognosis | OMICS International | Abstract
ISSN: 2329-6917

Journal of Leukemia
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Case Report

Acute Myeloid Leukemia with t(2;6)(q12;q12) Reveals Dysmegakaryopoietic Finding and Poor Prognosis

Jong Ae Son1, Kyung Ran Jun1*, Eul-Ju Seo2, Young-don Joo3, Seung Hwan Oh1, Ja Young Lee1, Jeong Hwan Shin1, Hye Ran Kim1 and Jeong Nyeo Lee1

1Department of Laboratory Medicine, Inje University College of Medicine, Busan, Korea

2Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea

3Department of Internal Medicine, Inje University College of Medicine, Busan, Korea

*Corresponding Author:
Kyung Ran Jun
Department of Laboratory Medicine
Haeundae Paik Hospital
Inje University College of Medicine
Jwa-dong, Haeundae-gu, Busan 612-030, Korea
Tel: 82-51-797-3191
Fax: 82-51-797-3194
E-mail: [email protected]

Received date Jul 22, 2013; Accepted date September 27, 2013; Published date September 30, 2013

Citation: Son JA, Jun KR, Joo Y, Oh SH, Lee JY, et al. (2013) Acute Myeloid Leukemia with t(2;6)(q12;q12) Reveals Dysmegakaryopoietic Finding and Poor Prognosis. J Leuk (Los Angel) 1:116. doi:10.4172/2329-6917.1000116

Copyright: © 2013 Son JA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

We present a case of acute myeloid leukemia (AML) with a balanced translocation between chromosomes 2q12 and 6q12, t(2;6)(q12;q12). This abnormality was defined by conventional cytogenetics and multicolor banding techniques using specific probes for chromosome 2. Blasts accounted for 2% of white blood cells in peripheral blood and approximately 30% of all nucleated cells in marrow aspirates. They were medium-to-large cells with fine nuclear chromatin, indistinct nucleoli and basophilic cytoplasm. Immunophenotyping indicated the blasts were of myeloid lineage with aberrant CD7 expression. Therefore, the patient was diagnosed as ‘Acute myeloid leukemia, NOS, AML with maturation’ according to the WHO classifications. In literature review, this case should be considered as the first report of AML with t(2;6)(q12;q12). Interestingly, a bone marrow smear showed dysmegakaryopoietic findings, such as multinucleated or mononucleated megakaryocytes and micromegakaryocytes. After diagnosis, the induction chemotherapy was given with idarubicin and cytosine arabinoside according to the protocol of intermediate-prognostic AML. After chemotherapy, the patient had been in remission for 13 months but relapsed with 54% blasts in marrow aspirates. The cytogenetic analysis revealed t(2;6)(q12;q12), which is same with karyotype shown at diagnosis. In this case report, the pathologic and clinical findings of AML with t(2;6)(q12;q12) were described, which are severe dysmegakaryopoiesis and poor prognosis. This report may be helpful for clinician to have a similar case treated

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