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Acute Myeloid Leukemia with Translocation (8;16)(p11;p13): A Distinct Syndromeand#195;and#162;and#194;and#8364;and#194;and#8220; Case Report and Literature Review | Abstract
ISSN: 2471-8556

Oncology & Cancer Case Reports
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Case Report

Acute Myeloid Leukemia with Translocation (8;16)(p11;p13): A Distinct Syndrome– Case Report and Literature Review

Naomi Dempsey1*, Moh’d Khushmann2, Peter Hosein1, Clifford Blieden3, Jennifer Chapman-Fredricks3 and Ronan Swords1

1University of Miami/Sylvester Cancer Center, Miami, USA

2University of South Alabama, USA

3University of Miami, Miami, USA

*Corresponding Author:
Dr. Naomi Dempsey
University of Miami/Sylvester Cancer Center
1611 NW 12th Ave. Miami, FL 33136, USA
Tel: 305-965-1864
E-mail: [email protected]

Received Date: August 09, 2017 Accepted Date: August 26, 2017 Published Date: August 30, 2017

Citation: Dempsey N, Khushmann M, Hosein P, Blieden C, Chapman-Fredricks J, et al. (2017) Acute Myeloid Leukemia with Translocation (8;16)(p11;p13): A Distinct Syndrome– Case Report and Literature Review. Oncol Cancer Case Rep 3: 134. doi: 10.4172/2471-8556.1000134

Copyright: © 2017 Dempsey N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Acute myeloid leukemia with the translocation (8;16)(p11;p13) is a rare type of acute leukemia with a number of unique features including erythrophagocytosis, extramedullary disease, and poor prognosis with high relapse rate. These cases of AML are often categorized as M4, M5a, or M5b AML under the FAB system of AML classification. However, the clinical and pathological features of AML with t(8;16) (p11;p13) do not fit into any of these French- American-British (FAB) classification system subtypes, nor is it recognized as a recurrent genetic abnormality within the WHO classification system. Here, we report the case of a 50-year-old female with a history of low-grade carcinoid tumor on surveillance who developed de novo AML with histiocytic differentiation and t(8;16)(p11;p13). Immunohistochemistry and morphology of the patient’s bone marrow biopsy was not consistent with any specific AML subtype, which resulted in diagnostic and therapeutic delays. AML with t(8;16)(p11;p13) has been described a number of times in the literature as a unique leukemic syndrome based on clinical, cytochemical, and DNA microarray features. As such, AML with t(8;16)(p11;p13) should be added to the WHO classification system list of AML with recurrent genetic abnormalities.

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