alexa Acute Submandibular Oncogenes in Myelodysplastic Syndrome: A Rare Report
ISSN: 2157-7552

Journal of Tissue Science & Engineering
Open Access

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Case Report

Acute Submandibular Oncogenes in Myelodysplastic Syndrome: A Rare Report

María Luisa Navarrete1*, Fernando Morell2, Juan Fernando Fuentes1, Nuria Ortiz1, Pilar Coscojuela3 and Angel García3

1Department of Otorhinolaryngology, Vall d’Hebron Hospital, Autonomous University of Barcelona, Spain

2Department of Pneumology, Vall d’Hebron Hospital, Autonomous University of Barcelona, Spain

3Department of NeuroRadiology and Pathology, Vall d’ Hebron Hospital, Autonomous University of Barcelona, Spain

Corresponding Author:
Dr. ML Navarrete
Department of Otorhinolaryngology
Vall d’ Hebron Hospital
Autonomous University of Barcelona, Spain
E-mail: [email protected]

Received date: February 08, 2012; Accepted date: March 07, 2012; Published date: March 09, 2012

Citation: Navarrete ML, Morell F, Fuentes JF, Ortiz N, Coscojuela P, et al. (2012) Acute Submandibular Tumour in Myelodysplastic Syndrome: A Rare Report. J Tissue Sci Eng 3:115. doi:10.4172/2157-7552.1000115

Copyright: © 2012 Navarrete ML, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Myelodysplastic syndromes (MDS) are hematological diseases with a wide clinical spectrum of manifestations. We present a 66 year old patient who was referred to our department with an acute submandibular growth that was first noticed 2 weeks ago. It hasn’t responded to standard treatment. Multiple studies were performed, and they revealed in filtrate of mielodisplastic cells, refractory anemia with excess blasts in transformation (RAEB-T) subtype according to the FAB classification. Combined chemotherapy couldn’t stop the disease’s progression and the patient died from a pulmonary infection 3 months after the onset of symptoms. Leukemic infiltration of the submandibular gland in mielodisplastic syndrome hasn’t been previously described in literature, so this seems to be the first reported case of extra medullary hematopoiesis resulting in an acute submandibular tumor in a patient with REAB-T.


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