alexa Additional Value of FDG PET and Resting State-functional MRI for the Assessment of Consciousness Disorders in Hypoglycemia-induced Coma
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
Open Access

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Case Report

Additional Value of FDG PET and Resting State-functional MRI for the Assessment of Consciousness Disorders in Hypoglycemia-induced Coma

Bund C1, Roquet D2, Noblet V2, Schenck-Dhif M3, Schneider F3, Kremer S2,4,5 and Namer IJ1,2,5*

1Department of Biophysics and Nuclear Medicine, University Hospital of Strasbourg, Strasbourg, France

2ICube, University of Strasbourg / CNRS (UMR 7357), Strasbourg, France

3Medical Intensive Care Unit, University Hospital of Strasbourg, Strasbourg, France

4Radiology and Hospital Hautepierre Service, University Hospital of Strasbourg, Strasbourg, France

5Translational Medicine Federation Strasbourg (WFSW), Faculty of Medicine, Strasbourg, France

*Corresponding Author:
Izzie-Jacques Namer
Biophysics Department and Nuclear Medicine
University Hospital of Strasbourg
Hospital de Hautepierre, 1, avenue
Molière, 67098 Strasbourg Cedex 09, France,
Tel: +33388127550
Fax: +33388128342
E-mail: [email protected]

Received date: January 28, 2016 Accepted date: February 10, 2016 Published date: February 17, 2016

Citation: Bund C, Roquet D, Noblet V, Schenck-Dhif M, Schneider F (2016) Additional Value of FDG PET and Resting State-functional MRI for the Assessment of Consciousness Disorders in Hypoglycemia-induced Coma. J Neurol Neurophysiol 7:355. doi:10.4172/2155-9562.1000355

Copyright: © 2016 Bund C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Background: Consciousness disorders in brain-injured patients are sometimes complicated to understand. The accuracy of the distinction between coma, vegetative state, minimally conscious state and locked-in syndrome can be improved by using functional imaging modalities, which is important because of the therapeutic impact.
Case presentation: We report a case of a 34 years old diabetic Caucasian woman whose glycemia had been previously tightly controlled with an insulin pump and who developed a profound coma overnight (spontaneous ventilation and Glasgow score 6) with transient ocular revulsions and intermittent crawling movements triggered by noxious stimuli at admission. At the 3rd day, 18F-fluorodeoxyglucose (FDG) PET and resting-state functional MRI (rs-fMRI) were performed when the patient spontaneously opened her eyes, but no evidence of awareness of the environment could be obtained. Awareness recovered progressively and follow-up imaging was performed on the 7th day when the patient presented only certain cognitive disorders. We demonstrated that rs-fMRI and FDG PET are non-invasive imaging tools that are helpful in the assessment of consciousness levels and residual cognitive disorders in patients with metabolic severe coma.


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