alexa Adenocarcinoma Ex Goblet Cell Carcinoid (GCC) of the Appendix: Report of Five Cases and Pitfalls in Diagnosis of GCC | OMICS International| Abstract

ISSN: 2471-2671

Archives of Surgical Oncology

  • Research Article   
  • Arch Surg Oncol 2016, Vol 2(1): 1
  • DOI: 10.4172/2471-2671.1000108

Adenocarcinoma Ex Goblet Cell Carcinoid (GCC) of the Appendix: Report of Five Cases and Pitfalls in Diagnosis of GCC

Jinhua Piao1, Jula Veerapong2, Zhenyan Li3, Edward Bolesta1, Nishant Poddar4 and Jin-Ping Lai1*
1Department of Pathology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA
2Department of Surgery, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA
3Division of Oncology, Washington University School of Medicine, Saint Louis, MO 63110, USA
4Division of Hematology-Oncology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA
*Corresponding Author : Jin-Ping Lai MD, PhD, Department of Pathology, Saint Louis University, 1402 South Grand Blvd, St. Louis, MO 63104, USA, Tel: 314-577-8475, Fax: 314-577-6132, Email: [email protected]

Received Date: Dec 02, 2015 / Accepted Date: Jan 08, 2016 / Published Date: Jan 14, 2016

Abstract

Neoplasm of the appendix is relatively rare. Only 0.9-1.4% of all appendectomy specimens is found to have it. One in particular is the adenocarcinoma ex goblet cell carcinoid. The exact histopathogenesis and pathologic classification of this neoplasm are yet to be elucidated. Herein we report five cases to emphasize the importance of meticulous sampling and the possibility of misdiagnosis due to the presence of diverticulitis and acute appendicitis in some of these patients. All of our patients initially were presented with symptoms of or mimicking appendicitis, with radiology imaging suggestive of acute appendicitis or an appendiceal abscess. The pathologic examination of the appendectomy specimen revealed the incidental finding of the adenocarcinoma ex goblet cell carcinoid with focal positivity of synaptophysin and chromogranin. Two of our patients had diverticulitis and perforated appendicitis, which may lead to a misdiagnosis of the goblet cell carcinoid due to the absence of a discrete mass formation and focal localization of these tumor cells. Therefore, meticulous sampling is imperative in the diagnosis of this entity

Keywords: Neoplasm; Adenocarcinoma; Interventional radiology; Streptococcus angiosus; Laparoscopic; Appendicitis

Citation: Piao J, Veerapong J, Li Z, Bolesta E, Poddar N, et al. (2016) Adenocarcinoma Ex Goblet Cell Carcinoid (GCC) of the Appendix: Report of Five Cases and Pitfalls in Diagnosis of GCC. Arch Surg Oncol 2: 108. Doi: 10.4172/2471-2671.1000108

Copyright: © 2016 Piao J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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