Adipose-Derived Stem Cells (ASC) Communicate with Residual Breast Cancer CellsReinkens T, Vogt PM and Bucan V*
Department of Plastic, Hand and Reconstructive Surgery, Medical School Hannover, Feodor-Lynen-Straße 21, 30625, Hannover, Germany
- *Corresponding Author:
- Dr. Vesna Bucan
Department of Plastic, Hand and Reconstructive Surgery
Medical School Hannover, Feodor-Lynen-Straße 21
30625, Hannover, Germany
E-mail: [email protected]
Received Date: May 02, 2017; Accepted Date: May 30, 2017; Published Date: June 02, 2017
Citation: Reinkens T, Vogt PM, Bucan V (2017) Adipose-Derived Stem Cells (ASC) Communicate with Residual Breast Cancer Cells. J Mol Genet Med 11:267 doi: 10.4172/1747-0862.1000267
Copyright: © 2017 Reinkens T, et al . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Purpose: Based on aesthetics and long-term stability, call-assisted autologous lipotransfer is a promising method for post-oncological breast reconstruction. Thereby, autologous fat grafts enriched with autologous adiposederived stem cells are transferred to the breast. However, as adipose-derived stem cells (ASC) have the ability to secrete exosomes and growth factors, they could communicate with residual breast cancer cells.
Methods: We performed a systematic review of the published literature to evaluate whether adipose-derived stem cells- based treatments for breast cancer are associated with tumor growth of rest breast cancer cells and therefore that it could exist an oncological risk. An electronic database search was performed.
Results: As described, all current studies can prove that the gene expression is influenced by the direct cell contact between adipose-derived stem cells and breast cancer cells.
Conclusion: These observations suggest that information is substituted via exosomes which can migrate intercellularly and transfer genetic material between both cell types.