Adipose-Lung Cell Crosstalk in the Obesity-ARDS ParadoxAna Fernandez-Bustamante and John E Repine*
Department of Anesthesiology & Webb-Waring Center, University of Colorado SOM, USA
- *Corresponding Author:
- John E Repine, MD
Director, Webb-Waring Center
University of Colorado SOM
12850 E Montview Blvd
Webb-Waring Center, V20
MS 322, Aurora, CO, 80045
E-mail: [email protected]
Received date: March 16, 2013; Accepted date: April 17, 2013; Published date: April 19, 2013
Citation: Bustamante AF, Repine JE (2013) Adipose-Lung Cell Crosstalk in the Obesity-ARDS Paradox. J Pulmon Resp Med 3:144. doi: 10.4172/2161-105X.1000144
Copyright: © 2013 Bustamante AF, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Obesity is an increasingly frequent condition associated with increased adipose, systemic and pulmonary inflammation. There is an emerging and unexpected finding that obese individuals may not be at a greater risk for ARDS and, indeed, may even be partially protected against ARDS. This finding is known as the Obesity-ARDS Paradox. In this review we discuss the observations regarding this intriguing phenomenon and begin to elaborate on the theoretical rationale that obesity-triggered low-grade inflammatory processes may constitute pre-conditioning insults or trigger anti-inflammatory adaptive mechanisms that confer protection against ARDS.