Adrenoleukodystrophy with Frontal Lobe Involvement and Attention Deficit Hyperactivity Disorder-like SymptomsYamashita Y1*, Ngagamitsu S1, Abe T2, Murakami Y3 and Matsuishi T4
- *Corresponding Author:
- Yushiro Yamashita
Department of Pediatrics and Child Health
Kurume University School of Medicine, 67 Asahi-Machi
Kurume City, Fukuoka
Tel: +81 942 31 7565
Fax: +81 942 38 1792
E-mail: [email protected]
Received date: August 12, 2015 Accepted date: October 09, 2015 Published date: October 15, 2015
Citation: Yamashita Y, Ngagamitsu S, Abe T, Murakami Y, Matsuishi T (2015) Adrenoleukodystrophy with Frontal Lobe Involvement and Attention Deficit Hyperactivity Disorder-like Symptoms. Int J Sch Cog Psychol S2:008. doi:10.4172/2469-9837.S2-008
Copyright: © 2015 Yamashita Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
We report a 11 year-old boy with adrenoleukodystrophy (ALD), who gradually became inattentive and hyperactive after ten years of age. His parents consulted with school counselor and were told that he might have attention deficit hyperactivity disorder (ADHD). We noticed his deterioration in intelligence and behavior and his cranial magnetic resonance imaging revealed bilateral abnormal intensity areas predominantly in the left frontal lobe to the basal ganglia, which surroundings was enhanced by Gd-DTPA suggesting demyelination. Statistical parametric mapping (SPM) using IMP single photon emission tomography showed decreased cerebral blood flow in the left frontal cortex, cerebellum, and brain stem. Abnormal levels of plasma very-long-chain fatty acids and genetic testing confirmed the diagnosis of ALD. His behavioral problems transiently improved with methylphenidate treatment, however he died in spite of bone marrow transplantation. This report emphasize that the importance of early medical evaluation when ADHD-like symptoms became prominent in a child who never had such problems before. Recognition of ADHD in the field of education enhanced after the recent promotion of special needs education. Necessity of medical evaluation in such a child to school teachers, nurses, counselors should be emphasized, so as not to be left undiagnosed and untreated.