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Journal of Molecular Biomarkers & Diagnosis
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Research Article

Adult Acute Biphenotypic Leukemias: Polish Single Centre Experience

J Aleksandra Butrym1,2*, Justyna Rybka1, Artur Jurczyszyn3, Jaroslaw Dybko1, Donata Urbaniak-Kujda1, Kazimierz Kuliczkowski1 and Grzegorz Mazur4

1Department of Hematology, Blood Neoplasms and Bone Marrow Transplantation, Wroclaw Medical University, Wroclaw, Poland

2Department of Physiology, Wroclaw Medical University, Wroclaw, Poland

3Department of Hematology, University Hospital, Krakow, Poland

4Department of Internal Medicine, Occupational Diseases and Hypertension, Wroclaw Medical University, Wroclaw, Poland

*Corresponding Author:
Aleksandra Butrym
Department of Hematology
Blood Neoplasms and Bone Marrow
Transplantation, Pasteur 4 Street, 50-367, Wroclaw
Wroclaw Medical University, Wroclaw, Poland
Tel: +48717842525
Fax: +48717840112
E-mail: [email protected]

Received Date: November 03, 2014; Accepted Date: December 27, 2014; Published Date: January 03, 2015

Citation: Butrym JA, Rybka J, Jurczyszyn A, Dybko J, Kujda DU, et al. (2015) Adult Acute Biphenotypic Leukemias: Polish Single Centre Experience. J Mol Biomark Diagn 6:209. doi:10.4172/2155-9929.1000209

Copyright: © 2015. Butrym JA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Biphenotypic AL (BAL) is characterised by presence of blasts which coexpress myeloid and T or B lineage antigens. In this study we describe the biological, clinical characteristic and outcome of 24 adult BAL patients treated in our center. We have analyzed a group of 480 patients with AL. To define BAL we used European Group for the Immunological Characterisation of Leukemias (EGIL) scoring system. Among whole group, 24 (5%) patients fulfilled the EGIL criteria of BAL. 22 patients were treated with conventional chemotherapy and in two cases allogeneic bone marrow transplantation from matched unrelated donors (MUD alloBMT) was performed. 50% of patients achieved complete remission. Ten patients died due to disease progression (no response after conventional therapy). In one case an extramedullary relapse after MUD alloBMT was a cause of death. Overall survival (OS) was 40%. Patients with BAL had poor outcome: induction of remission was difficult and overall survival was low.

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