Adult Acute Biphenotypic Leukemias: Polish Single Centre Experience
- *Corresponding Author:
- Aleksandra Butrym
Department of Hematology
Blood Neoplasms and Bone Marrow
Transplantation, Pasteur 4 Street, 50-367, Wroclaw
Wroclaw Medical University, Wroclaw, Poland
E-mail: [email protected]
Received Date: November 03, 2014; Accepted Date: December 27, 2014; Published Date: January 03, 2015
Citation: Butrym JA, Rybka J, Jurczyszyn A, Dybko J, Kujda DU, et al. (2015) Adult Acute Biphenotypic Leukemias: Polish Single Centre Experience. J Mol Biomark Diagn 6:209. doi:10.4172/2155-9929.1000209
Copyright: © 2015. Butrym JA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Biphenotypic AL (BAL) is characterised by presence of blasts which coexpress myeloid and T or B lineage antigens. In this study we describe the biological, clinical characteristic and outcome of 24 adult BAL patients treated in our center. We have analyzed a group of 480 patients with AL. To define BAL we used European Group for the Immunological Characterisation of Leukemias (EGIL) scoring system. Among whole group, 24 (5%) patients fulfilled the EGIL criteria of BAL. 22 patients were treated with conventional chemotherapy and in two cases allogeneic bone marrow transplantation from matched unrelated donors (MUD alloBMT) was performed. 50% of patients achieved complete remission. Ten patients died due to disease progression (no response after conventional therapy). In one case an extramedullary relapse after MUD alloBMT was a cause of death. Overall survival (OS) was 40%. Patients with BAL had poor outcome: induction of remission was difficult and overall survival was low.