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ISSN: 1948-5956

Journal of Cancer Science & Therapy
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Research Article

Adult Head and Neck Sarcomas: Rare Localization with Difficult Therapeutic Management

Karima Oualla1*, Nawfel Mellas1, Fatimazahra El’mrabet1, Samia Arifi1, Afaf Amarti2, Siham Tizniti3 and Omar Elmesbahi1

1Department of medical oncology, Hassan II University Hospital, Fez, Morocco

2Department of pathology, Hassan II University Hospital, Fez, Morocco

3Department of radiology, Hassan II University Hospital, Fez, Morocco

*Corresponding Author:
Karima Oualla
Department of medical oncology
Hassan II University Hospital, Fez-3000, Morocco
Tel: 00 212 676 61 02 67
Fax: 00 212 535 61 37 25
E-mail: [email protected]

Received date: January 17, 2014; Accepted date: February 20, 2014; Published date: February 24, 2014

Citation: Oualla K, Mellas N, El’mrabet F, Arifi S, Amarti A, et al. (2014) Adult Head and Neck Sarcomas: Rare Localization with Difficult Therapeutic Management. J Cancer Sci Ther 6:052-055. doi:10.4172/1948-5956.1000248

Copyright: © 2014 Oualla K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Head and neck sarcomas are very rare tumors, accounting less than 1% from all malignancies of this region. They represent a heterogeneous group of tumors with distinct prognostic features. There have been significant improvements in characterizing these sarcomas using traditional morphologic assessments and immunohistochemical analysis, but treatment management is still a big challenge. Prognostic factors are essentially tumor grade, margin status and tumor size. Surgery remains the mainstay of treatment, despite the anatomic constraints, followed by radiation therapy.

Aim: to show the rarity of the head and neck localization, and describe epidemiologic, clinico-radiological, histological features, treatment management and the evolution of these tumors.

Methods: It is a retrospective descriptive study conducted in the department of medical oncology at Hassan II University Hospital between January 2007 and December 2011, including all patients with histologically proven melanoma of the anorectal area.

Results: 10 cases were collected, that represented 7 % from all sarcomas reported at the study period. Five men and 5 women, the mean age was 34 years (range: 17-65years). Local imaging was performed by MRI in six cases and CT scan in 4 cases. It had showed locally advanced disease in 7 cases and among them 6 patients had a metastatic disease at the staging. Lung was the site of predilection of metastases. Histological analysis with the support of immunohisto-chemestry showed diverse histological subtypes. For the 3 cases with localized stages, the mainstay treatment was based on surgery followed by radiation therapy in one case with unclear margins. For metastatic stages, first line of chemotherapy was mainly based on: doxorubicin, ifosfamide, and cisplatine for osteosarcoma. Evolution was marked by disease controlee and remission in 2 patients who underwent surgery with clear margins. Unfortunately by recurrence in patient operated with unclear margins and by rapid progression for metastatic stages leading to death.

Conclusion: Adult head and neck sarcomas are very rare tumors with poor prognosis, high aggressiveness and rate of recurrence. They are frequently diagnosed at advanced stages. Treatment management is still a big challenge given to the difficulty of surgery and modest response to chemotherapy.

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