alexa Advances in Mass Spectrometry for Glycoscreening and Sequencing in Biomedical Research
ISSN: 2329-6798

Modern Chemistry & Applications
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Review Article

Advances in Mass Spectrometry for Glycoscreening and Sequencing in Biomedical Research

Adrian Robu1,2,4, Loredana Lupu1,2,4, Roshanak Aslebagh3, Alina D Zamfir1,2* and Costel C Darie3
1Mass Spectrometry Laboratory, National Institute of Research-Development for Electrochemistry and Condensed Matter, Timisoara, Romania, Plautius Andronescu Str.1, 300224, Timisoara, Romania
2Faculty of Physics, West University of Timisoara, Romania, Blvd. V. Parvan 4, 300223, Timisoara, Romania
3Biochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, 8 Clarkson Avenue Potsdam, NY, 13699-5810, USA
4These authors contributed equally to this work
Corresponding Author : Alina D Zamfir
Faculty of Physics, West University of Timisoara
Plautius Andronescu Street 1, 300224, Timisoara, Romania
Tel: 40-256-494-413;
E-mail: [email protected]
Received September 16, 2014; Accepted September 25, 2014; Published September 30, 2014
Citation:Robu A, Lupu L, Aslebagh R, Zamfir AD, Darie CC (2014) Advances in Mass Spectrometry for Glycoscreening and Sequencing in Biomedical Research. Mod Chem appl 2:138. doi:10.4172/2329-6798.1000138
Copyright: 2014 Robu A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

During the past several years, applications of Mass Spectrometry (MS) in the biomedical research increased considerably. While MS is for many years heavily used in proteomics, for protein identification and quantification as well as for biomarker discovery, for a long time its applications in glycomics were limited, mainly because of the challenging conditions required for the ionization and detection of most carbohydrate classes. However, due to the development of high performance analytical instrumentation, MS in particular with Electrospray (ESI) and Matrix Assisted Laser Desorption/Ionization (MALDI) started to be intensively applied also to the analysis of post-translational modifications such as glycosylation, acetylation or phosphorylation. Focus on MS-based glycosylation is, however, scarce. Therefore, analysis of glycoproteins in particular diseases through glycoscreening and sequencing is another new MS-based avenue, yet to be pursued. In this context, we discuss briefly here the recent advances of MS in glycomics and glycoscreening and their applications in biomedical research, with a particular emphasis on cancer, lysosomal storage and bacterial diseases.

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