alexa Advances in the Inhibitors of Janus Kinase
ISSN: 2161-0444

Medicinal Chemistry
Open Access

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Review Article

Advances in the Inhibitors of Janus Kinase

Jun-Jie J Jiang1, Xiao-Ying Wang1, Yv Zhang2, Yi Jin1* and Jun Lin1*

1Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry Education, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, P. R. China

2State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 201203, China

*Corresponding Author:
Yi Jin
Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University)
Ministry Education, School of Chemical Science and Technology
Yunnan University, Kunming, 650091, P. R. China
Tel/Fax: +86 871 503 3215
E-mail: [email protected]

Jun Lin
Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University)
Ministry Education, School of Chemical Science and Technology
Yunnan University, Kunming, 650091, P. R. China
Tel/Fax: +86 871 503 3215
E-mail: [email protected]

Received date: July 18, 2014; Accepted date: July 29, 2014; Published date: July 31, 2014

Citation: Jiang JJJ, Wang XY, Zhang Y, Jin Y, Lin J (2014) Advances in the Inhibitors of Janus Kinase. Med chem 4:540-548. doi:10.4172/2161-0444.1000192

Copyright: © 2014 Jiang JJJ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

The janus kinases (JAKs) comprise an important class of non-receptor protein tyrosine kinases. Cytokine and receptor binding can cause the activation of JAKs, and then activate the "signal transcripts and transcriptional activator”, making JAK enter the nucleus to induce target gene expression. JAKs regulate inflammatory diseases, bone marrow hyperplasia and a variety of malignant tumours. Using JAKs inhibitors as the therapy for organ transplantation and immune disease has a very important significance. In recent years, many of the JAKs inhibitors have been developed one after another. Pan JAKs inhibitor and selective JAK2 or JAK3 inhibitor research progress are reviewed in this article

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