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ISSN: 2329-8790

Journal of Hematology & Thromboembolic Diseases
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Review Article

Advances in the Treatment of Hairy Cell Leukemia

Anas Alsara1, Akshay Amaraneni2 and Sreenivasa R. Chandana3*
1Borgess Medical Center, Department of Internal Medicine, 1521 Gull Road, Kalamazoo, Michigan 49048, USA
2Western Michigan University Homer Stryker M.D. School of Medicine, Department of Internal Medicine, 1000 Oakland Drive, Kalamazoo, Michigan 49008, USA
3West Michigan Cancer Center, Department of Hematology and Oncology, 2000 N Park Street, Kalamazoo, Michigan 49007, USA, Divison of Hematology and Medical Oncology, Western Michigan University School of Medicine, Kalamazoo, Michigan, USA
Corresponding Author : Sreenivasa R. Chandana, MD, PhD
West Michigan Cancer Center
200 N. Park Street, Kalamazoo, MI, USA
Tel: 269 382 2500
Fax: 269 373 7478
E-mail: [email protected]
Received April 20, 2015; Accepted May 04, 2015; Published May 12, 2015
Citation: Alsara A, Amaraneni A, Chandana SR (2015) Advances in the Treatment of Hairy Cell Leukemia. J Hematol Thrombo Dis 3:210. doi:10.4172/2329-8790.1000210
Copyright: © 2015 Alsara A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Hairy cell leukemia is relatively rare, chronic low grade B-cell leukemia. It is characterized morphologically by cells with abundant cytoplasm and “hair”-like projections that can be found within the peripheral blood, bone marrow or splenic pulp. Like many cancers, the treatment for hairy cell leukemia has evolved considerably in the last several years. In the mid 1980s, the acceptable treatment was splenectomy and later interferon therapy, which is quickly falling out of favor with the advent and acceptance of purine analog therapy. In addition, we now have several biologic agents that are coming into favor based on their improved success and favorable toxicity. In addition, several studies are currently looking into the efficacy of purine analogs in conjunction with biologic agents. Rituximab, alemtuzumab and recombinant immunotoxins are being studied with limited success in hairy cell leukemia. The use of kinase inhibition is also being studied at this time. Advances in understanding the biology of hairy cell leukemia could potentially increase more treatment options.

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