Advantages of Psammomys obesus as an Animal Model to Study Diabetic RetinopathyT. Saidis1*, R. Ben Chaouacha-Chekir2 and D. Hicks1
- *Corresponding Author:
- Tounes Saidi
Departement de Neurobiologie des Rythmes
CNRS UPR 3212, Institut des Neurosciences Cellulaires et Intégratives
5 rue Blaise Pascal, 67084 Strasbourg Cedex, France
Tél: (33) 388 45 66 53
Fax: (33) 388 60 16 64
E-mail: [email protected]
Received date July 05, 2012; Accepted date August 07, 2012; Published date August 12, 2012
Citation: Saidi T, Chaouacha-Chekir RB, Hicks D (2012) Advantages of Psammomys obesus as an Animal Model to Study Diabetic Retinopathy. J Diabetes Metab 3:207. doi:10.4172/2155-6156.1000207
Copyright: © 2012 Saidi T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Psammomys obesus is an animal model of type 2 diabetes, which develops diabetic retinopathy as a result of chronic hyperglycemia after a high caloric diet. Distinctive features of induced diabetes in P. obesus are vascular structural abnormalities, elevated ratios of pro- to anti-angiogenic growth factors in the vitreous, blood-retinal barrier breakdown, neural and glial changes. Although many existing diabetic animal models develop ocular complications, retinal lesions frequently observed in diabetic patients such as preretinal neovascularization, retinal detachment and neovascular stages are only rarely observed in these models. Nevertheless, existing animal models are useful because preventing progressive capillary obliteration from occurring in the retina is likely to be a more beneficial therapeutic goal than merely inhibiting neovascularization in an already damaged and ischemic retina. This review
highlights recent observations regarding the histological changes seen in blood–retinal barrier breakdown, the alterations of macroglial and neuronal pattern in diabetes, and how these changes lead to vision loss. Although, the P. obesus will be a useful model in studies of the pathogenesis and treatment of diabetic retinopathy.