Adverse Effects of Soriatane on Rats Enterocytes: Light Microscopy and Ultrastructural Studies
Laila A. Hummadi*
Biology Department, Science Faculty for Girls, King Abdul-Aziz University, Saudi Arabia
- *Corresponding Author:
- Laila A. Hummadi
Biology Department, Science Faculty for Girls
King Abdul-Aziz University
Jeddah, Saudi Arabia
E-mail: [email protected]
Received Date: November 08, 2011; Accepted Date: February 22, 2012; Published Date: February 27, 2012
Citation: Hummadi LA (2012) Adverse Effects of Soriatane on Rats Enterocytes: Light Microscopy and Ultrastructural Studies. J Cytol Histol 3:133. doi:10.4172/2157-7099.1000133
Copyright: © 2012 Hummadi LA. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Soriatane (Acitretin) drug is a synthetic vitamin A analogue and the main metabolite of etretinate. It is considered to be the latest medicine prescribed to psoriasis patients. However, it is not used frequently because of its side-effect profile. Little is known about the Acitretin intestinal toxicity, so the objective of this study is evaluation of soriatane adverse events in daily practice treatment on the duodenum enterocytes of male rats. Two groups each of 10 Wistar male rats (5-6 weeks old), one of them is the treated group and the other is the control group. The drug was dissolved immediately in distilled water before administration, and given to treated rats by gastric intubation in the morning (0.2 mg/kg/day for 12 months), while the control group received only distilled water. A significant reduction in number and height of villi with increased mucosal thickness. Damage in the duodenum tissues with villi fusion, distortion flattened epithelial cells; intense lamina propria and edema were observed. The ultra-structure alterations were indicated by Golgi apparatus, rough endoplasmic reticulum and mitochondrial atrophy with cristiolysis. Proliferation of smooth endoplasmic reticulum, nuclear deformity and increased number of liposomes were also noted. It may concluded that Soriatane led to irreversible ultra- structural alterations in rat enterocytes after 12 months treatment and precautions should be taken in prescribing acitretin to patients.