alexa Aflatoxins and Hepatitis B, C Viral Associated Hepatocarcinogenesis
ISSN: 2157-7013

Journal of Cell Science & Therapy
Open Access

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Review Article

Aflatoxins and Hepatitis B, C Viral Associated Hepatocarcinogenesis

Humaira Qureshi1,2, Syed Shayan Ali1,2, Mazhar Iqbal3, Anwar Ali Siddiqui1, Naveed Ahmed Khan1* and Saeed S Hamid2

1Department of Biological and Biomedical Sciences,Aga Khan University, Karachi, Pakistan

2Department of Medicine, Aga Khan University, Karachi, Pakistan

3Drug Discovery & Structural Biology, Health Biotechnology Division, National Institute for Biotechnology & Genetic Engineering (NIBGE), Faisalabad, Pakistan

*Corresponding Author:
Naveed Ahmed Khan
Department of Biological and Biomedical Sciences
Aga Khan University, Karachi – 74800, Pakistan
Tel: +92-21-3486-4541
E-mail: [email protected]

Received Date: July 18, 2014; Accepted Date: September 27, 2014; Published Date: September 29, 2014

Citation: Qureshi H, Ali SS, Iqbal M, Siddiqui AA, Khan NA, et al. (2014) Aflatoxins and Hepatitis B, C Viral Associated Hepatocarcinogenesis. J Cell Sci Ther 5:179. doi: 10.4172/2157-7013.1000179

Copyright: © 2014 Qureshi H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Hepatocellular carcinoma is a serious human disease with fatal consequences. The most distressing aspect of hepatocellular carcinoma is the limited improvement in mortality (mortality rate of more than 90%). At present, the underlying molecular mechanisms are not well understood and treatment options are often of limited efficacy. This review presents our current understanding of the burden of hepatocellular carcinoma on human health, pathogenesis and pathophysiology, and molecular mechanisms associated with the disease, as well as our knowledge of the physical barriers, cellular mechanisms and molecular elements that may be targets for therapeutic interventions and/ or the development of preventative measures. As the proposed findings present a major risk to public health, it is hoped that robust intervention measures will be introduced for aflatoxins monitoring and reduction in diet.

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