Aflatoxins and Hepatitis B, C Viral Associated Hepatocarcinogenesis
- *Corresponding Author:
- Naveed Ahmed Khan
Department of Biological and Biomedical Sciences
Aga Khan University, Karachi – 74800, Pakistan
E-mail: [email protected]
Received Date: July 18, 2014; Accepted Date: September 27, 2014; Published Date: September 29, 2014
Citation: Qureshi H, Ali SS, Iqbal M, Siddiqui AA, Khan NA, et al. (2014) Aflatoxins and Hepatitis B, C Viral Associated Hepatocarcinogenesis. J Cell Sci Ther 5:179. doi: 10.4172/2157-7013.1000179
Copyright: © 2014 Qureshi H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Hepatocellular carcinoma is a serious human disease with fatal consequences. The most distressing aspect of hepatocellular carcinoma is the limited improvement in mortality (mortality rate of more than 90%). At present, the underlying molecular mechanisms are not well understood and treatment options are often of limited efficacy. This review presents our current understanding of the burden of hepatocellular carcinoma on human health, pathogenesis and pathophysiology, and molecular mechanisms associated with the disease, as well as our knowledge of the physical barriers, cellular mechanisms and molecular elements that may be targets for therapeutic interventions and/ or the development of preventative measures. As the proposed findings present a major risk to public health, it is hoped that robust intervention measures will be introduced for aflatoxins monitoring and reduction in diet.