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ISSN: 2161-0398

Journal of Physical Chemistry & Biophysics
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Review Article

AFM/TEM Complementary Structural Analysis of Surface-Functionalized Nanoparticles

Ruozi B1*, Belletti D1, Vandelli MA1, F Pederzoli1, P Veratti1, F Forni1, G Tosi1, Tonelli M2 and Zapparoli M2
1Department of Life Sciences, University of Modena and Reggio Emilia, Italy
2CIGS, Centro Interdipartimentale Grandi Strumenti, University of Modena and Reggio Emilia, Italy
Corresponding Author : Ruozi B
Department of Life Sciences
University of Modena and Reggio Emilia
Via Campi 183, 41124, Modena, Italy
Tel: +39.059.2055128
Fax: +39.0592055131
E-mail: [email protected]
Received May 08, 2014; Accepted June 28, 2014; Published June 30, 2014
Citation: Ruozi B, Belletti D, Vandelli MA, Pederzoli F, Veratti P, et al. (2014) AFM/ TEM Complementary Structural Analysis of Surface-Functionalized Nanoparticles. J Phys Chem Biophys 4:150. doi:10.4172/2161-0398.1000150
Copyright: © 2014 Ruozi B. et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

In the field of nanomedicine, the characterization of functionalized drug delivery systems, introduced on market as efficacious and selective therapeutics, represents a pivotal aspect of great importance. In particular, the morphology of polymeric nanoparticles, the most studied nanocarriers, is frequently assessed by transmission electron microscopy (TEM). Despite of TEM high resolution and versatility, this technology is frequently hampered by both the complicated procedure for sample preparation and the operative condition of analysis. Considering the scanning probe microscopies, atomic force microscopy (AFM) represents an extraordinary tool for the detailed characterization of submicron-size structure as the surface functionalization at the atomic scale. In this paper we discussed the advantage and limits of these microscopies applied to the characterization of PLGA nanoparticles functionalized with three different kinds of ligands (carbohydrate ligand, an antibody and quantum dots crystals) intentionally designed, created and tailored with specific physico-chemical properties to meet the needs of specific applications (targeting or imaging).

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