alexa Age of Salpingo-Oophorectomy and Risk of Peritoneal Carcinomatosis in Patients with a BRCA Mutation
ISSN: 1747-0862

Journal of Molecular and Genetic Medicine
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Research Article

Age of Salpingo-Oophorectomy and Risk of Peritoneal Carcinomatosis in Patients with a BRCA Mutation

Stjepanovic N1*, Carrasco E1, Gadea N1, Gil-Moreno A2, Perez A2, Diaz B2, Franco S2, Cabrera S2, Garcia A3, Castellvi J3, Oaknin A1, Díez O4,5, Bonache S4,5, Gutiérrez-Enríquez S4,5, Vilaro M5 and Balmaña J1,5

1Department of Medical Oncology, Vall d’Hebron Hospital, Universitat Autonoma de Barcelona, Spain

2Department of Gynecology, Vall d’Hebron Hospital, Universitat Autonoma de Barcelona, Spain

3Department of Pathology, Vall d’Hebron Hospital, Universitat Autonoma de Barcelona, Spain

4Department of Oncogenetics, Vall d’Hebron Hospital, Universitat Autonoma de Barcelona, Spain

5Vall d’Hebron Institute of Oncology (VHIO), Spain

Corresponding Author:
Neda Stjepanovic
Department of Medical Oncology, Vall d’Hebron University Hospital
P. Vall d’Hebron 119-129, 08035 Barcelona, Spain
Tel: 0034932746085
Fax: 0034932746059
E-mail: [email protected]

Received Date: October 08, 2015 Accepted Date: November 20, 2015 Published Date: November 27, 2015

Citation: Stjepanovic N, Carrasco E, Gadea N, Gil-Moreno A, Perez A, et al. (2015) Age of Salpingo-Oophorectomy and Risk of Peritoneal Carcinomatosis in Patients with a BRCA Mutation. J Mol Genet Med 9:190 doi:10.4172/1747-0862.1000190

Copyright: © 2015 Stjepanovic N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

 

Abstract

Background: Women with BRCA1/2 germline mutations who undergo bilateral salpingo-oophorectomy (BSO) are left with a residual risk of peritoneal serous carcinoma (PSC). We aimed to identify the incidence and risk factors for the development of PSC after BSO in BRCA1/2 mutation carriers. Methods: One-hundred-seventeen BRCA1/2 mutation carriers who underwent BSO were evaluated for further development of PSC. The BSO specimens were evaluated for occult Fallopian tube carcinoma (FTC), ovarian carcinoma (OVC) and serous tubal intraepithelial carcinoma (STIC) in all patients. P53-signature was available in 58 patients. Clinical data was obtained from patients’ charts. We calculated the association between clinical, pathological and molecular risk factors of PSC after BSO. Results: Analysis of BSO specimens revealed occult FTC in 1 woman (0.8%), STIC in 2 women (1.7%), and 6/58 women (10.3%) had a positive “p53 signature”. Older age at menopause (p=0.007) and shorter oral contraceptive use (p<0.001) were associated with FTC and STICs. The incidence of PSC after BSO was 1.7% (two patients). Both were BRCA2 mutation carriers and one had a history of STIC. The only risk factor identified for PSC after BSO was older age at surgery (63.5 years for patients with PSC vs. 48.6 years for patients without PSC, p<0.001). Conclusions: The incidence of PSC after BSO in our series is 1.7% and it is associated with an older age at BSO. Earlier menopause and oral contraceptive use seem to be associated with a decrease in the prevalence of occult FTC and STICs.

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