alexa Age-Associated Alterations of Morphology and ProteinSignaling in the Female F344xBN Rat Aorta
ISSN: 2167-7182

Journal of Gerontology & Geriatric Research
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Research Article

Age-Associated Alterations of Morphology and ProteinSignaling in the Female F344xBN Rat Aorta

Kevin M Rice2,3,4*, Jacqueline Fannin1, Radhakrishna Para2, Srinivasarao Thulluri1,3, WilliamTriest5, Paulete Wehner7 and Eric R Blough1,2,3,4,6
1Department of Pharmacology, Physiology, and Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington WV, USA
2Center for Diagnostic Nanosystems, Marshall University, Huntington WV, USA
3Cell Differentiation and Development Center, Marshall University, Huntington, WV, USA
4School of Kinesiology, College of Health Professions, Marshall University, Huntington WV, USA
5 Department of Pathology, VA Hospital, Huntington, WV, USA
6Department of Pharmaceutical Science Research, School of Pharmacy, Marshall University, Huntington WV, USA
7Department of Cardiology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA
Corresponding Author : Kevin M Rice
Center for Diagnostic Nanosystems
Marshall University, Huntington WV, USA
Tel: 304-638-2982
E-mail: [email protected]
Received December 16, 2014; Accepted January 25, 2015; Published January 27, 2015
Citation: Rice KM, Fannin J, Para R, Thulluri S, Triest W, et al. (2015) Age-Associated Alterations of Morphology and Protein Signaling in the Female F344xBN Rat Aorta. J Gerontol Geriatr Res 4:196. doi:10.4172/2167-7182.1000196
Copyright: © 2015 Rice KM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

The Fischer 344 x Brown Norway F1 (F344xBN) male rat has been shown to undergo many of the same age-associated vascular changes seen in humans [1]. However, limited research has been done to determine if the female F344xBN rat is a good aging female rodent model to study age-associated changes in the vasculature. Previously we reported cardiac increases in oxidative-nitrosative stress and mitochondrial-mediated apoptosis in this model [2]. Aortae from 6-, 26-, and 30-month female F344xBN rats were stained with hematoxylin and eosin, and a trichrome stain to determine intima-medial thickness and fibrosis, respectively. Age-associated changes in expression and phosphorylation of proteins were measured by immunoblotting. Aging in the female F344xBN rat was associated with an increase in aortic intima-medial thickness, activation of p44/42 MAPK, and Hsp27 expression and decreased activation of NF-κβ p50. Hsp90 expression decreased with age in the female F344xBN aorta. There were no age-associated changes in activation of eNOS or Akt or expression of the apoptotic regulators Bax and Bcl-2. Taken together, these data are consistent with the possibility that the female F344xBN rat may be an appropriate animal model to study age-associated changes in the cardiovascular system.

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