alexa Age-Related Human Nuclear Cataract. A Condition due to Inexorable Protein Deterioration | OMICS International | Abstract
ISSN: 2155-9570

Journal of Clinical & Experimental Ophthalmology
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Review Article

Age-Related Human Nuclear Cataract. A Condition due to Inexorable Protein Deterioration

Roger Truscott*
Illawarra Health and Medical Research Insitute, University of Wollongong, Northfields Ave, Wollongong, NSW 2522, Australia
Corresponding Author : Professor Roger Truscott
Illawarra Health and Medical Research Insitute
University of Wollongong
NSW, 2522, Australia
E-mail: [email protected]
Received December 26, 2012; Accepted February 22, 2013; Published February 28, 2013
Citation: Truscott R (2013) Age-Related Human Nuclear Cataract. A Condition due to Inexorable Protein Deterioration. J Clinic Experiment Ophthalmol S1:008. doi:10.4172/2155-9570-S1-008
Copyright: © 2013 Truscott R. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Nuclear cataract stems from the inexorable breakdown of long-lived macromolecules in the human lens. Although this realization is quite new, and the details of several events need to be determined, the overall framework is now reasonably clear. Racemisation, deamidation and truncation are the main drivers of protein denaturation, although understanding these processes leads to a conclusion that the prospects for reversing lens opacification are remote. Since age-related cataract appears to be inevitable, future strategies for slowing cataract formation may depend on a detailed examination of people who retain clear lenses into their eighth and ninth decades.

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