alexa Aggressive Natural Killer Cell Leukemia Secondary to Hodgkin Lymphoma: a Case Report and Review of the Literature
ISSN: 2167-7700

Chemotherapy: Open Access
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Case Report

Aggressive Natural Killer Cell Leukemia Secondary to Hodgkin Lymphoma: a Case Report and Review of the Literature

Meiyi Xu, Ying Yang, Xin Fu, Chunrui Li, Jianfeng Zhou, Li Meng and Danmei Xu*

Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China

*Corresponding Author:
Danmei Xu
Department of Hematology
Tongji Hospital, Tongji Medical College
Huazhong University of Science and Technology
Hubei, China
Tel: 86-27-83662680
Fax: 86-27-83662681
E-mail: [email protected]

Received Date: December 15, 2015; Accepted Date: January 04, 2016; Published Date: January 08, 2016

Citation: Xu M, Yang Y, Fu X, Li C, Zhou J (2016) Aggressive Natural Killer Cell Leukemia Secondary to Hodgkin Lymphoma: a Case Report and Review of the Literature. Chemo Open Access 5:182. doi: 10.4172/2167-7700.1000182

Copyright: © 2016 Danmei X, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



A 32-year old Chinese woman presented with high fever (39C), lymphadenopathy, hepatosplenomegaly, shortness of breath and general fatigue after initial remission of Hodgkin lymphoma (HL). The immuno-phenotype of blast cells found in her peripheral blood and pleural fluid suggested abnormal Natural Killer (NK) cells (CD2+CD3- CD56+CD45RO+HLADR+CD94+ with high Ki67). Her serum EB virus DNA was over 1.0×107IU/mL. Combining her clinical symptom and laboratory data, the patient was diagnosed with Hodgkin Lymphoma, secondary NK cell leukemia and haemophagocytic lymphohistocytosis (HLH). To date, this is the first reported case that developed secondary ANKL after the treatment of Hodgkin Lymphoma. Secondary treatment-related cancers are a major problem in HL survivors. Thus, novel treatment strategies for HL should aim at a reduction of chemotherapy and radiation therapy in order to reduce the risk for development of therapy-related malignancies. In conclusion, improvements of combined therapy as well as close monitoring during clinical follow up could warrant the improved overall survival of HL and prevent fatal complications.


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