AIDS-Related Kaposis sarcoma and Associated Immune Reconstitution Inflammatory SyndromeGemma Melé-Ninot1*, Joaquim Sola-Ortigosa1, Mònica Quintana-Codina1, Maribel Iglesias-Sancho1, Jordi Delás-Amat2 and Montse Salleras-Redonnet1
- *Corresponding Author:
- Gemma Melé-Ninot
Calle Viladomat 288 08029 Barcelona Spain
E-mail: [email protected]
Received date: January 02, 2016; Accepted date: February 20, 2016; Published date: February 27, 2016
Citation: Melé-Ninot G, Sola-Ortigosa J, Quintana-Codina M, Iglesias-Sancho M, Delás-Amat J, et al. (2016) AIDS-Related Kaposi’s sarcoma and Associated Immune Reconstitution Inflammatory Syndrome. Clin Microbiol 5:236. doi:10.4172/2327-5073.1000236
Copyright: © 2016 Melé-Ninot G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Kaposi's sarcoma (KS) associated with AIDS (AIDS-KS) is the most prevalent neoplasia among patients with AIDS. Its incidence has decreased dramatically in recent years due to the widespread use of highly active antiretroviral therapy (HAART). Paradoxically, in relation to the introduction of HAART it may occur a worsening or development of AIDS-KS despite the improvement of the immune function. This unusual process is called immune reconstitution syndrome in Kaposi's sarcoma (IRIS-KS) and should not be confused with a failure of HAART. Early identification of AIDS-KS and previous or combined use of chemotherapy with HAART appears to be the most effective treatment to prevent the consequences of IRIS-SK.