alexa Airway Hyperresponsiveness and Inflammation: Causation, Correlation, or No Relation? | OMICS International
ISSN: 2155-6121

Journal of Allergy & Therapy
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Research Article

Airway Hyperresponsiveness and Inflammation: Causation, Correlation, or No Relation?

Yvonne MW Janssen-Heininger1, Charles G. Irvin2, Erich V Scheller3, Amy L Brown1, Jay K Kolls3 and John F Alcorn3*

1Department of Pathology, University of Vermont, Burlington, VT, USA

2Department of Medicine, University of Vermont, Burlington, VT, USA

3Department of Pediatrics, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA

*Corresponding Author:
John F. Alcorn
Department of Pediatrics Children’s Hospital of Pittsburgh of UPMC
One Children’s Hospital Dr., 4401 Penn Ave
9127 Rangos, Pittsburgh, PA 15224, USA
Tel:
412-692-7595
Fax:
412-692-5695
E-mail:
[email protected]

Received Date: November 14, 2011; Accepted Date: January 22, 2012; Published Date: January 26, 2012

Citation: Janssen-Heininger YMW, Irvin CG, Scheller EV, Brown AL, Kolls JK, et al. (2012) Airway Hyperresponsiveness and Inflammation: Causation, Correlation, or No Relation? J Aller Ther S1:008. doi: 10.4172/2155-6121.S1-008

Copyright: © 2012 Janssen-Heininger YMW, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Asthma represents a growing problem in the developing world, affecting millions of children and adults. Features of the disease are reversible airflow obstruction, airway hyperresponsiveness and airway inflammation leading to tissue damage and remodeling. Many studies have attempted to address whether inflammation and airway hyperresponsiveness are mechanistically linked.

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