alexa Albumin Supplementation to Cold Injection Solution increases Viability of Endothelial and Smooth Muscle Cells | OMICS International
ISSN: 2157-7013

Journal of Cell Science & Therapy
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Research Article

Albumin Supplementation to Cold Injection Solution increases Viability of Endothelial and Smooth Muscle Cells

Samer Srouji1,2*, Mizied Falah3, Yifat Haritan3, Itai Tzchori3 and Moshe Flugelman3,4

1Department of Anatomy and Cell Biology, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

2Department of Oral and Maxillofacial Surgery, Carmel Medical Center, Haifa, Israel

3MultiGene Vascular Systems Ltd, Lady Davis Carmel Medical Center, Israel

4Ruth and Bruce Rappaport Faculty of Medicine, Technion, IIT, Haifa, Israel

*Corresponding Author:
Samer Srouji
Department of Anatomy and Cell Biology
Rappaport Faculty of Medicine
Technion-Israel Institute of Technology, Haifa, Israel
Tel: 972 4-829-2111
E-mail: [email protected]

Received Date: August 20, 2014; Accepted Date: September 25, 2014; Published Date: September 27, 2014

Citation: Srouji S, Falah M, Haritan Y, Tzchori I, Flugelman M (2014) Albumin Supplementation to Cold Injection Solution increases Viability of Endothelial and Smooth Muscle Cells. J Cell Sci Ther 5:177. doi: 10.4172/2157-7013.1000177

Copyright: © 2014 Srouji S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Cell-based therapies have become one of the leading fields of human genetics, where administration of certain cell suspensions now constitutes a potential treatment for various diseases. However, common injection solutions may not sufficiently preserve cell stability and functionality beyond certain times. The present study investigates whether albumin improves viability of endothelial and smooth muscle cells suspended within injection solution. Cells were extracted from vein segments, cultured and suspended in injection solutions supplemented with 1%, 2.5% or 5% albumin and incubated at 4°C for 24 and 48 hours. The viability of both cell lines at 24 hours was found to be significantly higher (P<0.001) when cultured with any of the three albumin concentrations, compared to the control albumin-free solution. Furthermore, the 2.5% albumin-containing solution promoted cell adherence, compared to the control, after 24 hours in culture. These results imply the potential of albumin in preserving cell viability for clinical purposes.

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