alexa Alcohol Consumption as a Risk Factor for Abdominal Aortic Aneurysm | OMICS International | Abstract
ISSN: 2329-6925

Journal of Vascular Medicine & Surgery
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Review Article

Alcohol Consumption as a Risk Factor for Abdominal Aortic Aneurysm

Ben L Green1, Marc A Bailey1,2*, Katherine I Bridge1,2, Kathryn J Griffin1,2 and Julian A Scott1,2

1Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds LS2 9JT, UK

2The Leeds Vascular Institute at the Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK

*Corresponding Author:
Mr Marc A Bailey, MBChB BSc MRCS
British Heart Foundation Fellow in Vascular Surgery
The Leeds Vascular Institute, The General Infirmary at Leeds
Great George Street, Leeds LS1 3EX, UK
Tel: +44 (0) 7879816005, +44 (0) 113 3923196
Fax: +44 (0) 1133922624
E-mail: [email protected], [email protected]

Received Date: May 02, 2014; Accepted Date: June 09, 2014; Published Date: June 11, 2014

Citation: Green BL, Bailey MA, Bridge KI, Griffin KJ, Scott JA (2014) Alcohol Consumption as a Risk Factor for Abdominal Aortic Aneurysm. J Vasc Med Surg 2:140. doi: 10.4172/2329-6925.1000140

Copyright: © 2014 Green BL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Introduction: Abdominal aortic aneurysm (AAA) represents a major cause of death in the over 65 age group. Current evidence suggests that AAA development may be due to an immune mediated inflammatory response leading to degradation of the extracellular matrix, increased biomechanical wall stress and resultant aortic dilatation. Modifiable risk factors include hypertension and smoking; however the potential role of alcohol remains unclear.

Methodology: The electronic databases EMBASE, Pubmed, Medline and Web of Science were searched using key word search terms in conjunction with Boolean operators based on the PRISMA recommendations (‘Ethanol’ OR ’alcohol‘) AND (“aneurysm” OR ’abdominal aortic aneurysm‘ OR ’AAA’). Articles considering an association between alcohol and patients with and without AAA were included, based on title, keyword and abstract screen. No limitation was imposed by year, methodology or language. Reference lists of included studies and pertinent journal contents were hand searched for additional suitable studies.

Results: A total of eight articles were identified for inclusion, the majority of which were retrospective and prospective cohort studies. Five of the studies reported a positive association between alcohol and AAA; however one reported a loss of association following adjustment for confounders, including smoking. Three further studies reported no association, although in two Scandinavian studies, alcohol consumption was considerably lower compared with those reporting a positive association.

Conclusion: Existing evidence is limited but may suggest a link between high levels of alcohol consumption and AAA development, whilst moderate consumption may confer some protection. Further epidemiological study is required.


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