Alcohol Drinking, Non-alcoholic Beverages and Risk of Advanced Prostate Cancer among Uruguayan Men
- *Corresponding Author:
- Dr. Eduardo De Stefani
Avenida Brasil 3080 department 402
11300 Montevideo, Uruguay
Tel: +598 7081240
E-mail: [email protected]
Received Date: September 27, 2011; Accepted Date: November 01, 2011; Published Date: November 03, 2011
Citation: De Stefani E, Deneo-Pellegrini H, Ronco AL, Boffetta P, Acosta G (2011) Alcohol Drinking, Non-alcoholic Beverages and Risk of Advanced Prostate Cancer among Uruguayan Men. J Cancer Sci Ther S1:006 . doi: 10.4172/1948-5956.S1-006
Copyright: © 2011 De Stefani E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Loss of the membrane endopeptidase CD10 plays an important role in the development of neuropeptide-mediated androgen-independent prostate cancer cell growth. The aim of this study was to investigate the potential prognostic value of the CD10/neuropeptide axis with regard to prostate-specific antigen (PSA) failure after radical prostatectomy (RP) in early prostate cancer (PC) patients.
Methods: Tumor samples from 70 early PC patients who underwent RP were immunohistochemically evaluated for expression of CD10 and endothelin-1 (ET-1). The examined parameters were prospectively correlated with time to PSA failure and combined with Gleason grade and pathological TNM stage.
Results: Membranous and apical cytoplasmic expression of CD10 was directly correlated with time to PSA failure ( P < 0.001). Cytoplasmic ET-1 was inversely correlated with time to PSA relapse ( P = 0.002). CD10 and ET-1 were inversely interrelated ( P < 0.001). CD10 expression (P = 0.012) and stage ( P = 0.013) were independent predictors of biochemical recurrence.
Conclusion: CD10 and ET-1 follow inverse patterns of expression in tumors of early PC patients, in accordance with their biological roles and molecular interrelations. Evaluation of CD10 expression in early PC might contribute to a better prediction of PSA relapse-free survival after RP.