Alcohol Use Disorder and Inflammatory Cytokines in a Population Sample of Young AdultsAlethea Zago1, Fernanda Pedrotti Moreira1, Karen Jansen1,5,6, Alfredo Cardoso Lhullier2, Ricardo Azevedo da Silva1, Jacqueline Flores de Oliveira1, João Ricardo Carvalho Medeiros1, Gabriela Delevati Colpo5, Luis Valmor Portela3, Diogo R. Lara4, Luciano Dias de Mattos Souza1, Jean Pierre Oses1,5,6* and Carolina David Wiener1
- Corresponding Author:
- Jean Pierre Oses
Neuroscience Laboratory of Clinical Graduate Program in Health and Behavior,
Science Center of Life and Health, Catholic University of Pelotas, Gonçalves Chaves
373 Room 324 Building C, Central 96015-560 Pelotas, Brazil
E-mail: [email protected]
Received date: March 21, 2016; Accepted date: April 24, 2016; Published date: April 29, 2016
Citation: Zago P, Moreira FP, Jansen K, Lhullier AC, da Silva RA, et al. (2016) Alcohol Use Disorder and Inflammatory Cytokines in a Population Sample of Young Adults. J Alcohol Drug Depend 4:236. doi:10.4172/2329-6488.1000236
Copyright: © 2016 Zago A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Alcohol abuse is followed by neuroadaptive brain changes, in addition to inducing changes in the immune system. The objective of this study was to investigate the peripheral levels of proinflammatory (IL-6, and TNF-α) and anti-inflammatory (IL-10) cytokines, as well the inflammatory balance in relation to alcohol use in subjects from a young population-based sample.
Methods: This is a cross-sectional study nested in a population-based study of people aged 18–35 years, involving 629 participants. The CAGE questionnaire was used to evaluate Alcohol Use Disorder, and CAGE scores ≥ 2 were considered a positive screen for alcohol use disorder. Serum levels of IL-6, IL-10 and TNF-α were measured by ELISA using a commercial kit.
Results: There was as a statistically significant increase in IL-6 (p ≤ 0.001) and statistically significant decrease in IL-10 (p=0.017) serum levels in the Alcohol Use Disorder group when compared with subjects that did not abuse alcohol and that a CAGE score <2. TNF-α levels were not significantly different. There was a statistically significant difference in IL-6/IL-10 (p ≤ 0.001). The median ratios were 0.28 (0.20 to 0.36) in the CAGE group with scores <2 and 0.70 (0.52 to 0.93) in the group with alcohol use disorder for the IL-6/IL-10.
Conclusion: Our results suggest that cytokines, especially IL-6 and IL-10, are involved in the pathophysiology of abuse and dependence of alcohol, and could be candidate markers of alcohol use disorder.