alexa Alcoholic Liver Disease and Alcohol in Non-Alcoholic Liver Disease: Does it Matter?
ISSN: 2167-0943

Journal of Metabolic Syndrome
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Review Article

Alcoholic Liver Disease and Alcohol in Non-Alcoholic Liver Disease: Does it Matter?

Lesmana CRA*
Department of Internal Medicine, Hepatology Division, Cipto Mangunkusumo Hospital, Digestive Disease & GI Oncology Center, Medistra Hospital, Jakarta, Indonesia
Corresponding Author : Lesmana CRA
Department of Internal Medicine
Cipto Mangunkusumo Hospital
Digestive Disease & GI Oncology Center
Medistra Hospital, Jakarta, Indonesia
Tel: 62 21 5210200
E-mail: [email protected]
Received March 29, 2014; Accepted June 21, 2014; Published June 25, 2014
Citation: Lesmana CRA (2014) Alcoholic Liver Disease and Alcohol in Non-Alcoholic Liver Disease: Does it Matter?. J Metabolic Synd 3:147. doi:10.4172/2167-0943.1000147
Copyright: © 2014 Lesmana CRA. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Alcoholic Liver Disease (ALD) is still a major problem in Western and Asian countries. The long-term impact of ALD might further lead to liver disease complications, such as liver cirrhosis and liver cancer. The safe limit amount of alcohol might be different between Western and Asian countries as the genetic factor might also become an important role in the liver disease progression. It is well-known that alcohol consumption would have synergistic liver injury effect together with chronic viral hepatitis infection. However, in non-alcoholic fatty liver disease (NAFLD), mild to moderate alcohol consumption might have a beneficial effect as it might protect the liver. Further studies will be needed to confirm the beneficial effect of mild to moderate alcohol consumption for protecting the liver as the liver disease progression in many countries might have different influenced factors, especially in chronic viral hepatitis infection due to different genetic polymorphism and different virus genotype distribution. Obesity, which is now becoming one of the biggest problems in NAFLD patients, it would also give a different prognosis in liver disease progression between Western and Asian countries because of different type of food habits and lifestyle. Alcohol consumption issue would become the emerging controversies issue in the near future as NAFLD is now becoming an emerging disease despite chronic viral hepatitis infection.

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