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Allogeneic Mesenchymal Stem Cells Injections for the Treatment of Bronchiolitis Obliterans Syndrome Following Allogeneic Hematopoietic Stem Cells Transplant | Abstract
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

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Research Article

Allogeneic Mesenchymal Stem Cells Injections for the Treatment of Bronchiolitis Obliterans Syndrome Following Allogeneic Hematopoietic Stem Cells Transplant

Wei Liang1,2*, Hailong Xia2, Yongqing Wang2 and Robert Chunhua Zhao2

1The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China

2Institute of Basic Medical Science and School of Basic Medicine, Center of Excellence in Tissue Engineering, Chinese Academy of Medical Science and Peking Union Medical College and Tsinghua University, Beijing, China

*Corresponding Author:
Wei Liang M.D
The Department of Oncology
The First Affiliated Hospital of Anhui Medical University, China
Tel/Fax: 86-0551-2922844
E-mail: [email protected]

Received Date: June 13, 2012; Accepted Date: July 06, 2012; Published Date: July 09, 2012

Citation: Liang W, Xia H, Wang Y, Zhao RC (2012) Allogeneic Mesenchymal Stem Cells Injections for the Treatment of Bronchiolitis Obliterans Syndrome Following Allogeneic Hematopoietic Stem Cells Transplant. J Cancer Sci Ther 4: 185-187. doi: 10.4172/1948-5956.1000138

Copyright: © 2012 Liang W, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Bronchiolitis Obliterans Syndrome (BOS) is a well-recognized complication of allogeneic Hematopoietic Stem Cell Transplantation (HSCT). The management of bronchiolitis obliterans has been frustrating, with patients developing progressive Air Flow Obstruction (AFO). The purpose of this study was to evaluate the efficacy of human Bone Marrow Derived Mesenchymal Stem Cells (BMMSC) as the salvage therapy for BOS after HSCT. One patient with BOS received intravenous infusions of BMMSC at a dose of 1.5×106/kg per patients’ weight, and rapid recovery from BOS without any side effects was observed. We concluded that BMMSC seems to be a promising therapeutic method in patients with BOS after HSCT.

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