alexa Allotransplantation and Its Association with Rising Inc
ISSN: 0974-8369

Biology and Medicine
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Opinion Article

Allotransplantation and Its Association with Rising Incidence of Cancers

Gogichadze TG and Gogichadze GK*

*Department of Microbiology and Immunology, Tbilisi State Medical University, 33, Vazha-Pshavela Ave., Tbilisi, 01776, Georgia, USA

*Corresponding Author:
Gogichadze GK
Department of Microbiology and Immunology
Tbilisi State Medical University, 33
Vazha-Pshavela Ave., Tbilisi, 01776, Georgia, USA
Tel: +995 599 511 160
E-mail: [email protected]

Received Date: September 26, 2014; Accepted Date: October 28, 2014; Published Date: November 04, 2014

Citation: Gogichadze and Gogichadze (2014) Allotransplantation and Its Association with Rising Incidence of Cancers. Biol Med (Aligarh) 6:216. doi:10.4172/0974-8369.1000216

Copyright: © 2014 Gogichadze, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



In some cases of allotransplantation, simultaneous development of malignant tumors of different histogenesis may be observed. We propose to consider malignant tumor formation during allotransplantations in terms of karyogamic theory of carcinogenesis. Experience in transplantology tentatively testify that even in cases of maximal antigen compatibility of donors and recipients, immune conflict is unavoidable. As we believe, in immunological conflict between recipient and donor cells, the process of cells’ destruction in some cases may be accompanied by damages of plasma membranes and somatic hybridization between immunocompetent cells of the recipient and any cell of transplanted donor’s tissue, which may lead to the emergence of a cancer cell. Antibodies and cytotoxic cells can induce damages (perforations) of different degree on somatic cells plasma membranes, which can represent firstly the precancerous and later the true cancerous cells formation.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version