Allotransplantation and Its Association with Rising Incidence of Cancers
Gogichadze TG and Gogichadze GK*
*Department of Microbiology and Immunology, Tbilisi State Medical University, 33, Vazha-Pshavela Ave., Tbilisi, 01776, Georgia, USA
- *Corresponding Author:
- Gogichadze GK
Department of Microbiology and Immunology
Tbilisi State Medical University, 33
Vazha-Pshavela Ave., Tbilisi, 01776, Georgia, USA
Tel: +995 599 511 160
E-mail: [email protected]
Received Date: September 26, 2014; Accepted Date: October 28, 2014; Published Date: November 04, 2014
Citation: Gogichadze and Gogichadze (2014) Allotransplantation and Its Association with Rising Incidence of Cancers. Biol Med (Aligarh) 6:216. doi:10.4172/0974-8369.1000216
Copyright: © 2014 Gogichadze, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
In some cases of allotransplantation, simultaneous development of malignant tumors of different histogenesis may be observed. We propose to consider malignant tumor formation during allotransplantations in terms of karyogamic theory of carcinogenesis. Experience in transplantology tentatively testify that even in cases of maximal antigen compatibility of donors and recipients, immune conflict is unavoidable. As we believe, in immunological conflict between recipient and donor cells, the process of cells’ destruction in some cases may be accompanied by damages of plasma membranes and somatic hybridization between immunocompetent cells of the recipient and any cell of transplanted donor’s tissue, which may lead to the emergence of a cancer cell. Antibodies and cytotoxic cells can induce damages (perforations) of different degree on somatic cells plasma membranes, which can represent firstly the precancerous and later the true cancerous cells formation.