alexa Alphavirus Vectors in Vaccine Development | OMICS International | Abstract
ISSN: 2157-7560

Journal of Vaccines & Vaccination
Open Access

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Review Article

Alphavirus Vectors in Vaccine Development

Kenneth Lundstrom*

PanTherapeutics, Lutry, Switzerland

*Corresponding Author:
Kenneth Lundstrom
PanTherapeutics, Lutry, Switzerland
E-mail: [email protected]

Received Date: October 21, 2012; Accepted Date: June 14, 2012; Published Date: June 20, 2012

Citation: Lundstrom K (2012) Alphavirus Vectors in Vaccine Development. J Vaccines Vaccin 3:139. doi: 10.4172/2157-7560.1000139

Copyright: © 2012 Lundstrom K. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The high-level heterologous gene expression provided by alphavirus vectors has accelerated their applications in vaccine development. The versatility of alphavirus vectors has allowed their use in the form of recombinant viral particles, naked RNA and layered DNA molecules for immunization. The most commonly used alphaviruses have been Semliki Forest virus, Sindbis virus and Venezuelan Equine Encephalitis virus. Numerous viral structural proteins have been used as antigens to generate neutralizing antibodies in immunized animals. Vaccination has demonstrated protection against challenges with lethal doses of viruses. Moreover, vaccination with tumor antigens has demonstrated prophylactic protection against cancer. Novel approaches include the application of RNA interference and microRNA. The other side of the coin is the development of vaccines against alphaviruses themselves, and typically the Chikungunya virus.

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