alexa Alterations in Tissue Structure and Morphology in Apo E-KO Mice: The Impact of Dietary Lipids and Heart Transplantation
ISSN: 2157-7099

Journal of Cytology & Histology
Open Access

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Review Article

Alterations in Tissue Structure and Morphology in Apo E-KO Mice: The Impact of Dietary Lipids and Heart Transplantation

Moghadasian MH1,2*

1Department of Human Nutritional Sciences and the Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Hospital Research Centre and the University of Manitoba, Canada

2International Nutrition Research Inc., Winnipeg, Canada

*Corresponding Author:
Moghadasian MH
International Nutrition Research Inc
351 Tache Ave Winnipeg
Canada R2H 2A6
Tel: 2042353934
Fax: 2042374018
Email: [email protected]

Received Date: January 05, 2016 Accepted Date: January 23, 2016 Published Date: January 25, 2016

Citation: Moghadasian MH (2016) Alterations in Tissue Structure and Morphology in Apo E-KO Mice: The Impact of Dietary Lipids and Heart Transplantation. J Cytol Histol 7:393. doi:10.4172/2157-7099.1000393

Copyright: © 2016 Moghadasian MH. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



In this article, the impact of dietary lipids and heterotopic heart transplant procedures on the structure and morphology of several tissues in apolipoprotein E-knock out (apo E-KO) mice is reported. In particular, addition of dietary cholesterol, plant sterol or either changes in hemodynamic factors or immunological responses after heart transplant procedures are associated with histological and cytological changes in the kidneys, skin, heart and arteries in this animal model. In this report, alterations in the vessel wall structure and morphology including formation of atherosclerotic plaques, infiltration of macrophages, as well as evidence for rejection of the donor hearts and formation of non-specific vacuolation in the liver and kidney have been illustrated. In conclusion, various factors may cause changes in tissue structure and morphology which may lead to tissue dysfunction. Early detection of such changes and appropriate remedies including dietary and lifestyle modifications may help sustain tissue structure and function.

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