alexa Altered Hematological and Biochemical Parameters in Schoolchildren Living in an Agricultural Community of Merida State, Venezuela | OMICS International | Abstract
ISSN: 2161-0525

Journal of Environmental & Analytical Toxicology
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Research Article

Altered Hematological and Biochemical Parameters in Schoolchildren Living in an Agricultural Community of Merida State, Venezuela

Leticia Miranda-Contreras1*, Jesus Alfonso Osuna2, Ibis Cruz1, Yasmin Morales1, Nolis Camacho3, Rosanna Cicchetti3, Iraida Salazar4, Melisa Colmenares1, Alirio Balza1, Leisalba Zavala1 and Beluardi Sanchez1

1Electron Microscopy Center “Dr. Ernesto Palacios Prü”, University of Los Andes, Merida, Venezuela

2Laboratory of Andrology, Faculty of Medicine, University of Los Andes, Merida, Venezuela

3Department of Pediatric Endocrinology, University Hospital of Los Andes, Merida, Venezuela

4Hematology Unit, Department of Medicine, University Hospital of Los Andes, Merida, Venezuela

*Corresponding Author:
Leticia Miranda-Contreras
Universidad de Los Andes, Centro de Microscopia Electronica
“Dr. Ernesto Palacios Prü”, Calle 32 entre
Avenidas 4 y Tulio Febres Cordero
Bulevar de Los Estudiantes
Merida 5101, Venezuela
Tel: 582742403166/3160
Fax: 582742403156
E-mail: [email protected] (or) [email protected]

Received date: January 16, 2017; Accepted date: January 25, 2017; Published date: January 30, 2017

Citation: Miranda-Contreras L, Osuna JA, Cruz I, Morales Y, Camacho N, et al. (2017) Altered Hematological and Biochemical Parameters in Schoolchildren Living in an Agricultural Community of Merida State, Venezuela. J Environ Anal Toxicol 7:431. doi:10.4172/2161-0525.1000431

Copyright: © 2017 Miranda-Contreras L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Epidemiological studies have found that children living in a pesticide treated farmland have higher risk of developing cancer or other serious health problems. Their exposure to pesticides could be limited by periodic health assessments; however, there are few biomarkers for pesticide exposure. The aim of this work was to examine the effects of chronic exposure to pesticides on hematological and biochemical parameters in farm-resident children compared to urban-resident control children. A cross-sectional study was conducted in 72 farm schoolchildren and 41 controls; a follow-up study was done two years later on 20 participants. The children underwent a clinical examination, nutritional assessment, and blood sampling for complete hemogram and biochemical analysis of liver and renal functions, lipid and glucose metabolism, plasma cholinesterase, thyroid hormones and total antioxidant capacity. A prevalence of malnutrition and undernutrition were found in both exposed and control children. The most important hematological results were thrombocytosis in 48% of farm children, increased mean lymphocyte and monocyte counts, and decreased mean neutrophil counts compared to control. Butyrylcholinesterase activity was diminished in 35% of farm children. Alterations in biochemical parameters were observed between exposed and control groups, however, most of the results were within normal limits, except for the significant decrease in total antioxidant capacity. Follow-up study 2 years later showed normalized platelet and lymphocyte counts, however, decreased neutrophil counts was still observed. This study demonstrates that children living in an agricultural community are exposed to the health hazards of pesticides. Undernutrition and improper dental hygiene affect childrens' overall health status and are likely to increase their vulnerability to toxic effects of pesticides.


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