alexa Aluminum?s Role in CNS-immune System Interactions leading to Neurological Disorders
ISSN: 1745-7580

Immunome Research
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Research Article

Aluminum?s Role in CNS-immune System Interactions leading to Neurological Disorders

Shaw CA1,2,3*, Kette SD4, Davidson RM5 and Seneff S6

1Neural Dynamics Research Group, Department of Ophthalmology and Visual Sciences, 828 W. 10th Ave., Vancouver, British Columbia, V5Z1L8, Canada

2Program Experimental Medicine, University of British Columbia, Vancouver, V5Z1L8, Canada

3Program in Neurosciences, University of British Columbia, Vancouver, V5Z1L8, Canada

4Independent researcher, Hudson, FL 34667, USA

5Internal Medicine Group Practice, PhyNet, Inc., 4002 Technology Center, Longview, TX 75605, USA

6MIT Computer Science and Artificial Intelligence Laboratory, 32 Vassar Street, Cambridge, MA 02139, USA

Corresponding Author:
Shaw CA
Neural Dynamics Research Group
Department of Ophthalmology and Visual Sciences
Research Pavilion, 828 W. 10th Ave., Vancouver
British Columbia, V5Z1L8, Canada
E-mail: [email protected]

Received date: October 05, 2013; Accepted date: October 25, 2013; Published date: October 30, 2013

Citation: Shaw CA, Kette SD, Davidson RM, Seneff S (2013) Aluminum’s Role in CNS-immune System Interactions leading to Neurological Disorders. Immunome Res 9:069. doi: 10.4172/1745-7580.1000069

Copyright: © 2013 Shaw CA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Multisystem interactions are well established in neurological disorders, in spite of conventional views that only the central nervous system (CNS) is impacted. We review evidence for mutual interactions between the immune and nervous systems and show how these seem to be implicated in the origin and progression of nervous system disorders. Well-established immune system triggers leading to autoimmune reactions are considered. Of these, aluminum, a known neurotoxicant, may be of particular importance. We have demonstrated elsewhere that aluminum has the potential to induce damage at a range of levels in the CNS leading to neuronal death, circuit malfunction, and ultimately system failure. Aluminum is widely used as an adjuvant in various vaccine formulations and has been implicated in a multisystem disorder termed ?autoimmune/inflammatory syndrome induced by adjuvants? (ASIA). The implications of aluminum-induced ASIA in some disorders of the CNS are considered.?We propose a unified theory capturing a progression from a local response to a systemic response initiated by disruption of water-based interfaces of exposed cells.

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