alexa Alu-repeat Polymorphism in the Tissue Plasminogen Activator Gene and Risks of Myocardial Infarction in Tunisian Population
ISSN: 2161-0444

Medicinal Chemistry
Open Access

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Research Article

Alu-repeat Polymorphism in the Tissue Plasminogen Activator Gene and Risks of Myocardial Infarction in Tunisian Population

Raoudha Bahri1, Awatef Msolly2* and Asma Kassab2

1Laboratory of Human Genetics and Anthropology, Faculty of Pharmacy, Monastir, Tunisia

2Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Monastir, Tunisia

*Corresponding Author:
Awatef Msolly
Department of Biochemistry and Molecular Biology
Faculty of Pharmacy
Monastir 5000, Tunisia
Tel: 00216- 97867155
E-mail: [email protected]

Received date: January 25, 2016; Accepted date: February 02, 2016; Published date: February 05, 2016

Citation: Bahri R, Msolly A, Kassab A (2016) Alu-repeat Polymorphism in the Tissue Plasminogen Activator Gene and Risks of Myocardial Infarction in Tunisian Population. Med chem 6:072-074. doi:10.4172/2161-0444.1000327

Copyright: © 2016 Bahri R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



This study aimed to determine whether I/D polymorphism predispose to the development of MI in Tunisia. 50 patients with coronary artery disease complicated by MI and 70 healthy controls were analyzed. Quantitative analyses lipids are founded. DNA was isolated from blood samples. Polymorphisms were assessed by polymerase chain reaction method. Statistical differences between groups were determined by Chi-square test. Compared to controls, cases have significantly higher levels of total cholesterol, triglycerides and LDL-cholesterol and lower level of HDL-cholesterol. There are no significant differences between patients and controls in terms of allelic and genotypic frequencies. However, the frequency of the “I” allele is higher in cases which have 2 MI (p=0.0354). Additionally, a statistically significant association between diabetes, arterial high blood pressure, family history and cigarette smoking with MI was founded (p<0.01). I/D polymorphism of t-PA gene is not associated with MI in this sample of Tunisian population.


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