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Alzheimer Diseases: Substituted Spiro [2.3andprime;] Oxindolespiro [3.2andPrime;]-5, 6-Dimethoxy-Indane-1andPrime;-One- Indolizine Analogue as Inhibitors of Acetylcholinesterase | Abstract
ISSN: 2161-0444

Medicinal Chemistry
Open Access

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Research Article

Alzheimer Diseases: Substituted Spiro [2.3′] Oxindolespiro [3.2″]-5, 6-Dimethoxy-Indane-1″-One- Indolizine Analogue as Inhibitors of Acetylcholinesterase

Mohamed Ashraf Ali1*, Rusli Ismail1, Tan Soo Choon1, Raju Suresh Kumar2, Mohammad Asad2, Abdulrahman I.Almansour3, Yeong Keng Yoon1, Ang Chee Wei1, Karthikeyan Elumalai5 and Suresh Pandian4

1Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Minden 11800, Penang, Malaysia

2School of Chemical Science, Universiti Sains Malaysia, Minden 11800, Penang, Malaysia

3Department of Chemistry, College of Sciences, King Saud University, P.O.Box 2455, Riyadh 11451, Saudi Arabia

4New Drug Discovery Research, Department of Medicinal Chemistry, Alwar Pharmacy College, Alwar, Rajasthan-301030, India

5New Drug Discovery Research,Sunrise University,Alwar,Rajasthan-301030

*Corresponding Author:
Mohamed Ashraf Ali
Institute for Research in Molecular Medicine
Universiti Sains Malaysia
Minden 11800, Penang, Malaysia
E-mail:[email protected]

Received date: December 08, 2011; Accepted date: February 23, 2012; Published date:February 24, 2012

Citation: Ali MA, Ismail R, Choon, Kumar RS, Asad M, et al. (2012) Alzheimer Diseases: Substituted Spiro [2.3′] Oxindolespiro [3.2″]-5, 6-Dimethoxy-Indane-1″- One- Indolizine Analogue as Inhibitors of Acetylcholinesterase. Medchem 2:106. doi:10.4172/2161-0444.1000106

Copyright: © 2012 Ali MA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Indanone derivatives share vital pharmacological properties, considered useful in alzheimer’s disease (AD).The aim of this study was synthesis and evaluate indolizine analogues if possess acetyl cholinesterase (AChE)inhibitory activity. The easily accessible three-step synthesis of these compounds resulted to be significantly less difficult and expensive than that of donepezil. Several compounds possess anti-cholinesterase activity in the order of micro and sub-micromolar. Particularly, compound 3k was the most potent inhibitors of the series. Compound 3k, showed potent inhibitory activity against acetyl cholinesterase enzyme with IC50 0.10 μmol/L. Indolizine analogues might be potential acetyl cholinesterase agents for AD.

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