alexa Amide-based Disulfide Building Blocks for the Enlargement of the Solid Phase Peptide Synthesis for Molecular Diagnostics and Imaging
ISSN: 2167-7689

Pharmaceutical Regulatory Affairs: Open Access
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Research Article

Amide-based Disulfide Building Blocks for the Enlargement of the Solid Phase Peptide Synthesis for Molecular Diagnostics and Imaging

Braun K1*, Wiessler M1, Komljenovic D1, Schrenk HH1, Lorenz P1, Fleischhacker H1, Waldeck W2 and Pipkorn R3

1German Cancer Research Center, Department of Imaging and Radio Oncology, INF 280, D-69120 Heidelberg, Germany

2German Cancer Research Center, Division of Biophysics of Macromolecules, INF 580, D-69120 Heidelberg, Germany

3German Cancer Research Center, Central Peptide Synthesis Unit, INF 580, D-69120 Heidelberg, Germany

*Corresponding Author:
Braun K
German Cancer Research Center (DKFZ)
Department of Imaging and Radio Oncology
Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany
Tel: +49 6221-42 3329
Fax: +49 6221-42 3326
E-mail: [email protected]

Received date: October 04, 2013; Accepted date: January 24, 2014; Published date: January 31, 2014

Citation: Braun K, Wiessler M, Komljenovic D, Schrenk HH, Lorenz P, et al. (2014) Amide-based Disulfide Building Blocks for the Enlargement of the Solid Phase Peptide Synthesis for Molecular Diagnostics and Imaging. Pharmaceut Reg Affairs 3:115. doi:10.4172/2167-7689.1000115

Copyright: © 2014 Braun K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Progress in genome and proteome research led to a deeper insight in differential gene expression processes. This required the use of sensitive and specific tools in diagnostics; also new promising patient-specific therapy attempts are conceivable. Nucleic acids were up till now a critical goal for diagnostic applications and therapeutic interventions, but in future they can serve as highly sequence-specific tools in molecular diagnostics. Examples for diagnostic Molecular Imaging modalities are the analysis of metabolic processes which can lead to customized therapeutic approaches (“Targeted Therapy”). The solid phase peptide synthesis SPPS is considered as an excellent tool in the individualized medicine with nucleic acids which increasingly play a key role as a drug. This requires new properties of the nucleic acid-based drugs, contiguous to the stability in biological systems, a high variability by combination with functional peptide-based molecules or with reformulated drugs or imaging components. The multifaceted application spectrum is dependent on the patients’ individual differential gene expression profiles or on the medical questionnaire. Here we show a new synthesis strategy able to circumvent ligations steps and to enhance the yields in the SPPS technology by use of a novel disulfide-containing monomer. This molecule acts as a disulfide linker which can overcome the common occasional losses occurring during established coupling reactions, like disulfide-bridge formations.

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