Amoebicidal Effect of Poly (Maleic Anhydride-Co-Vinyl Acetate) Copolymer on Entamoeba Histolytica TrophozoitesGulderen Karakus1*, Ali Fazil Yenidunya1, Haci Bayram Zengin2, Erdogan Malatyali3 and Semra Özçelik3
- *Corresponding Author:
- Dr. Gulderen Karakus
Research Center of the Cumhuriyet University School of Medicine CUTFAM-RCCUSM
58140 Sivas Turkey
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E-mail: [email protected]
Received date: September 22, 2011; Accepted date: November 08, 2011; Published date: December 25, 2011
Citation: Karakus G, Yenidunya AF, Zengin HB, Malatyali E, Özçelik S (2011) Amoebicidal Effect of Poly (Maleic Anhydride-Co-Vinyl Acetate) Copolymer on Entamoeba Histolytica Trophozoites. Medchem 1:103. doi:10.4172/2161-0444.1000103
Copyright: © 2011 Uguroglu S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Poly (maleic anhydride-co-vinyl acetate) (MAVA) copolymer was synthesized by free-radical copolymerization in methyl ethyl ketone (MEK) at 80ºC, using benzoyl peroxide (BPO) as the initiator. The radical chain copolymerization was confirmed by Fourier Transform Infrared (FTIR) and Nuclear Magnetic Resonance (1H-NMR) spectra. Copolymer surface morphology was visualized by scanning electron microscopy (SEM). After these characterization studies, the amoebicidal effect of MAVA was investigated on E.histolytica trophozoites using differing copolymer concentrations and periods of time. Results indicated that MAVA killed all the trophozoites at 32 mg/mL concentration in 3 h.