alexa Amoebicidal Effect of Poly (Maleic Anhydride-Co-Vinyl A
ISSN: 2161-0444

Medicinal Chemistry
Open Access

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Research Article

Amoebicidal Effect of Poly (Maleic Anhydride-Co-Vinyl Acetate) Copolymer on Entamoeba Histolytica Trophozoites

Gulderen Karakus1*, Ali Fazil Yenidunya1, Haci Bayram Zengin2, Erdogan Malatyali3 and Semra Özçelik3

1Research Center of the Cumhuriyet University School of Medicine, CUTFAM-RCCUSM, 58140 Sivas Turkey

2Department of Chemistry, Cumhuriyet University, 58140 Sivas, Turkey

3Department of Parasitology, School of Medicine, Cumhuriyet University, 58140 Sivas, Turkey

*Corresponding Author:
Dr. Gulderen Karakus
Research Center of the Cumhuriyet University School of Medicine CUTFAM-RCCUSM
58140 Sivas Turkey
strong>Tel: +90 346 2191156
Fax: +90 346 2191155
E-mail: [email protected]

Received date: September 22, 2011; Accepted date: November 08, 2011; Published date: December 25, 2011

Citation: Karakus G, Yenidunya AF, Zengin HB, Malatyali E, Özçelik S (2011) Amoebicidal Effect of Poly (Maleic Anhydride-Co-Vinyl Acetate) Copolymer on Entamoeba Histolytica Trophozoites. Medchem 1:103. doi:10.4172/2161-0444.1000103

Copyright: © 2011 Uguroglu S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Poly (maleic anhydride-co-vinyl acetate) (MAVA) copolymer was synthesized by free-radical copolymerization in methyl ethyl ketone (MEK) at 80ºC, using benzoyl peroxide (BPO) as the initiator. The radical chain copolymerization was confirmed by Fourier Transform Infrared (FTIR) and Nuclear Magnetic Resonance (1H-NMR) spectra. Copolymer surface morphology was visualized by scanning electron microscopy (SEM). After these characterization studies, the amoebicidal effect of MAVA was investigated on E.histolytica trophozoites using differing copolymer concentrations and periods of time. Results indicated that MAVA killed all the trophozoites at 32 mg/mL concentration in 3 h.


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