alexa An Adaptive Evolution of Helicobacter pylori: Role of the CagA Presence in the Outcome of H. pylori Eradication in Children
ISSN: 2161-0665

Pediatrics & Therapeutics
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Research Article

An Adaptive Evolution of Helicobacter pylori: Role of the CagA Presence in the Outcome of H. pylori Eradication in Children

Alexander A Nijevitch*, Bulat Idrisov, Ekaterina Kuchina, Fanil Bilalov and Elsa N Akhmadeeva

Bashkortostan State Medical University, Pediatrics Department, 3 Lenina St., Ufa, Russia

*Corresponding Author:
Alexander A Nijevitch
Bashkortostan State Medical University
Pediatrics Department
3 Lenina St., Ufa, Russia, 450008
E-mail: [email protected]

Received Date: June 05, 2013; Accepted Date: July 25, 2013; Published Date: July 28, 2013

Citation: Nijevitch AA, Idrisov B, Kuchina E, Bilalov F, Akhmadeeva EN (2013) An Adaptive Evolution of Helicobacter pylori: Role of the CagA Presence in the Outcome of H. pylori Eradication in Children. Pediat Therapeut 3:164. doi:10.4172/2161-0665.1000164

Copyright: © 2013 Nijevitch AA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Introduction: The aim of the study was to determine the evolutionary role of the Cag A presence in the outcome of eradication treatment of H. pylori.
Materials and methods: Sixty-seven pediatric dyspeptic patients (mean age 13.7 years, range 5 to 17 years, male/female 24/43) underwent endoscopy for H.pylori presence. Gastric biopsy specimens were taken for histology and/or culture and one biopsy sample was used for CagA PCR determination. H. pylori positive patients were treated for 2 weeks by amoxycilline (50 mg/kg/day), bismuth subcitrate (8 mg/kg/day), nifuratel (30 mg/kg/day) plus omeprazole (1 mg/kg, once daily).
Results: Forty one of 67 children (61.2%) were H. pylori positive. Nineteen of 41 strains (46.3%) were CagA positive and 22 were CagA negative (53.7%). H. pylori was eradicated in 33 patients (80.4%). Among the patients with successful eradication 18 children were CagA positive, fourteen were CagA negative.
Thus, more patients with CagA-negative status had evidence of ongoing H. pylori infection (36.4% (8/22) versus 5.3% (1/19); χ2=4.08, p=0.0021; Fisher’s exact test p= 0.0238).
Conclusion: In our study the carriage of CagA-lacking strain was associated with failure of treatment. In our opinion, this phenomenon, related to extraordinary genome plasticity, not only allows the microbe to maintain balanced relationship with the host, but also to survive in antibacterial therapy conditions.
 

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