alexa An Adaptive Evolution of Helicobacter pylori: Role of t
ISSN: 2161-0665

Pediatrics & Therapeutics
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

An Adaptive Evolution of Helicobacter pylori: Role of the CagA Presence in the Outcome of H. pylori Eradication in Children

Alexander A Nijevitch*, Bulat Idrisov, Ekaterina Kuchina, Fanil Bilalov and Elsa N Akhmadeeva

Bashkortostan State Medical University, Pediatrics Department, 3 Lenina St., Ufa, Russia

*Corresponding Author:
Alexander A Nijevitch
Bashkortostan State Medical University
Pediatrics Department
3 Lenina St., Ufa, Russia, 450008
E-mail: [email protected]

Received Date: June 05, 2013; Accepted Date: July 25, 2013; Published Date: July 28, 2013

Citation: Nijevitch AA, Idrisov B, Kuchina E, Bilalov F, Akhmadeeva EN (2013) An Adaptive Evolution of Helicobacter pylori: Role of the CagA Presence in the Outcome of H. pylori Eradication in Children. Pediat Therapeut 3:164. doi:10.4172/2161-0665.1000164

Copyright: © 2013 Nijevitch AA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Introduction: The aim of the study was to determine the evolutionary role of the Cag A presence in the outcome of eradication treatment of H. pylori.
Materials and methods: Sixty-seven pediatric dyspeptic patients (mean age 13.7 years, range 5 to 17 years, male/female 24/43) underwent endoscopy for H.pylori presence. Gastric biopsy specimens were taken for histology and/or culture and one biopsy sample was used for CagA PCR determination. H. pylori positive patients were treated for 2 weeks by amoxycilline (50 mg/kg/day), bismuth subcitrate (8 mg/kg/day), nifuratel (30 mg/kg/day) plus omeprazole (1 mg/kg, once daily).
Results: Forty one of 67 children (61.2%) were H. pylori positive. Nineteen of 41 strains (46.3%) were CagA positive and 22 were CagA negative (53.7%). H. pylori was eradicated in 33 patients (80.4%). Among the patients with successful eradication 18 children were CagA positive, fourteen were CagA negative.
Thus, more patients with CagA-negative status had evidence of ongoing H. pylori infection (36.4% (8/22) versus 5.3% (1/19); χ2=4.08, p=0.0021; Fisher’s exact test p= 0.0238).
Conclusion: In our study the carriage of CagA-lacking strain was associated with failure of treatment. In our opinion, this phenomenon, related to extraordinary genome plasticity, not only allows the microbe to maintain balanced relationship with the host, but also to survive in antibacterial therapy conditions.

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version