alexa An Additional risk of Lung Cancer from Recurrent Exposure to Ethyl Carbamate (EC) in BALB/C Mice
ISSN: 1948-5956

Journal of Cancer Science & Therapy
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Research Article

An Additional risk of Lung Cancer from Recurrent Exposure to Ethyl Carbamate (EC) in BALB/C Mice

Mohamed A Hamzawy1*, Amira M Abo-youssef2, Heba F Salem3 and Sameh Mohamed A2

1Faculty of Pharmacy , Pharmacology and Toxicology Department, Beni-Suef University, Beni-Suef, Egypt

2Pharmacology and Toxicology Department, College of Pharmacy, Misr University for Science and Technology, 6th October City, Egypt

3Pharmaceutics Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt

*Corresponding Author:
Hamzawy MA
Misr University for Science and Technology
P.O.Box: 77, 6th of October City
Egypt Al-Motamayez District, Egypt
Tel: 201001842988
E-mail: [email protected]

Received date: October 27, 2015; Accepted date: November 28, 2015; Published date:November 30, 2015

Citation: Hamzawy MA, Abo-youssef AM, Salem HF, Sameh Mohamed A (2015) An Additional risk of Lung Cancer from Recurrent Exposure to Ethyl Carbamate (EC) in BALB/C Mice. J Cancer Sci Ther 7:359-362. doi:10.4172/1948-5956.1000374

Copyright: © 2015 Hamzawy MA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Ethyl carbamate (EC); urethane is a chemical carcinogen (IARC group 2A). It has been commonly found in the fermented food and beverages. EC induced cancerous lesion in different sites due to the formation of active metabolite; vinyl carbamate (VC). The current study aims to investigate the potential risk of cancerous lesions in small and repeated exposure of ethyl carbamate in BALB/C mice. Three groups of BALBL/C mice were treated for 120 days included untreated control; group treated with a single dose of urethane (1.5 g/kg B.w/i.p) at a day one; group treated with repeated doses, the first at a day one and a second at day sixty (1.5g/ kg B.w/i.p). Ethyl carbamate (EC) exposure showed sever changes of serum biochemical markers, apoptosis markers, inflammatory cytokines as well as lipid peroxide formation in lung homogenate, these changes were pronounced in repeated exposure to ethyl carbamate. In addition, histological examinations revealed that epithelial changes in pulmonary tissues were advanced in animals treated with repeated doses of ethyl carbamate. These findings indicate that repeated exposure to ethyl carbamate of fermented foods and beverages is an additional risk for lung cancer due to permanent mitochondrial dysfunction and increase the cellular mitotic activity.

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