alexa An Amino Acid-Oligosaccharide Complex Increases Mineral Bioavailability In Vitro
ISSN: 2376-1318

Vitamins & Minerals
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Research Article

An Amino Acid-Oligosaccharide Complex Increases Mineral Bioavailability In Vitro

Rabovsky AB1* and William Diehl-Jones2
1Research and Technology Development, Melaleuca, Inc. Idaho Falls, ID, USA
2Faculty of Health Disciplines, Athabasca University, University Drive, Athabasca, AB, Canada
Corresponding Author : Alexander Rabovsky
Research and Technology Development
Melaleuca, Inc. Idaho Falls, ID, USA
Tel: 208-522-0700
E-mail: [email protected]
Received July 22, 2015; Accepted August 12, 2015; Published August 20, 2015
Citation: Rabovsky AB, Diehl-Jones W (2015) An Amino Acid-Oligosaccharide Complex Increases Mineral Bioavailability In Vitro. Vitam Miner 3:132. doi:10.4172/2376-1318.1000132
Copyright: © 2015 Rabovsky AB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Limitations in the efficacy of mineral supplements include poor solubility at intestinal pH, low bioavailability and, particularly in the case with iron and copper, catalysis of oxidation. To address these limitations we tested a novel amino acid-oligosaccharide complex in a previously-validated in vitro digestion/absorption system. A proprietary multimineral/ multivitamin admixture in either the novel organic or inorganic mineral forms were subjected to simulated gastric and intestinal digestion, followed by apical exposure to Caco-2/HT-29MTX enterocyte co-cultures. Bioavailability was assessed by minerals and ascorbic acid analysis of fluid from the basolateral culture compartment. Intracellular oxidative flux was measured using the fluorescent probe 5-(and-6)-chloromethyl-2, 7-dichlorodihydrofluorescein diacetate acetyl ester (CM-H2 DCFDA). Compared to the inorganic mineral form, the organic matrix yielded significant increases in mineral solubility, and yielded several-fold increases in basolateral concentrations of all minerals tested (manganese 3.3x; copper 3.1x; iron 2.1x; and zinc 4.4x) compared to the inorganic matrix. Cells exposed to the organic formulation also had significantly lower levels of intracellular oxidation after a one-hour treatment. We conclude that the amino acid oligo-fructose formulation significantly increases mineral and ascorbic acid bioavailability and decreases intracellular oxidative stress in vitro.

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