alexa An Analysis of the Safety and Efficacy of Topical Zinc-Thymulin to treat Androgenetic Alopecia | OMICS International | Abstract
ISSN: 2167-0951

Hair Therapy & Transplantation
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Research Article

An Analysis of the Safety and Efficacy of Topical Zinc-Thymulin to treat Androgenetic Alopecia

Vickers ER*

Pain Management and Research Centre, University of Sydney, Australia

*Corresponding Author:
Vickers ER
Director of Clinical Stem Cells Pty Ltd., Australia
Tel: +61427711888
E-mail: [email protected]

Received date: January 09, 2017; Accepted date: January 18, 2017; Published date: January 26, 2017

Citation: Vickers ER (2017) An Analysis of the Safety and Efficacy of Topical Zinc-Thymulin to treat Androgenetic Alopecia. Hair Ther Transplant 7:147. doi:10.4172/2167-0951.1000147

Copyright: © 2017 Vickers ER. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Objective: To assess the safety and efficacy of the metallopeptide zinc-thymulin (ZT) for treating androgenetic alopecia (AGA). Previous in vitro studies have described that different thymic peptides can both increase and decrease anagen (thymulin and thymosin beta-4, respectively). Zinc is an essential element and serum zinc deficiency can cause hair loss.

Methods: Eighteen consecutive adult subjects were recruited, 17 males and 1 female, age range 35-90 years (mean 55.4, SD 13.3) with a diagnosis of AGA, Norwood classification 2-7, and hair loss duration range of 3-40 years (mean 15.8, SD 9.6). The trial duration for each subject ranged from 4-10 months. The test compound ZT was synthesized by standard Fmoc peptide protocols and administered in water based topical spray to the scalp. Baseline and after treatment images for hair growth were graded by two blinded assessors using two validated scales: 1. numerical visual analog scale (VAS) for global assessment 2. hair growth index (HGI) of images under higher magnification for percentage changes of vellus, intermediate and terminal hair.

Results: ZT demonstrated no adverse systemic effects or local side effects of redness or scalp irritation in any subject over a total of 3,300 treatment days. Three subjects who were concurrently using minoxidil (N=2) and minoxidil / finasteride (N=1) did not report any drug interaction with ZT. VAS hair assessment improvement was significant in subjects who completed 6 months of treatment (P=0.045, t-test). HGI assessment showed a significant increase in the number of newly observed intermediate hairs in previous “absent hair” regions (P<0.0001) with an average increase of vellus type (32%) and intermediate type (23%) hairs at 6 months. Melanogenesis was observed in several subjects.

Conclusion: Topical applications of ZT demonstrated safety and established efficacy for initiating and maintaining anagen to treat male pattern baldness when applied for>6 months.

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