alexa An Atom-economic and Facile Synthesis of Novel 4-Imino-
ISSN: 2161-0444

Medicinal Chemistry
Open Access

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Research Article

An Atom-economic and Facile Synthesis of Novel 4-Imino-3-phenyl-2- substitutedphenyl-5-tolyl-2H,3H,5H[1,2,5]thiadiazolidine-1-oxide through 1,3-Dipolar Cycloaddition Reactions

Vasudha Kaushal, Anjandeep Kaur* and Baldev Singh

Department of Chemistry, Punjabi University, Patiala, Punjab, India

*Corresponding Author:
Anjandeep Kaur
Department of Chemistry
Punjabi University
Patiala-147 002, Punjab, India
Tel: +91-9872666431
E-mail: [email protected]

Received date: November 06, 2015; Accepted date: November 20, 2015; Published date: November 25, 2015

Citation: Kaushal V, Kaur A, Singh B (2015) An Atom-economic and Facile Synthesis of Novel 4-Imino-3-phenyl-2-substitutedphenyl-5-tolyl-2H,3H,5H[1,2,5] thiadiazolidine-1-oxide through 1,3-Dipolar Cycloaddition Reactions. Med chem 5:484-488. doi: 10.4172/2161-0444.1000306

Copyright: © 2015 Kaushal V, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



An atom economic and facile synthesis of novel thiadiazolidine-1-oxides has been achieved via using 1,3-dipolar cycloaddition reactions. The salient features of synthetic procedure are characterized by the good yields, high regio- and stereoselectivity, one-pot procedure, and operational simplicity. The regiochemistry and structures of the cycloadducts were determined by using various spectroscopic techniques (IR, 1H-NMR, ESI-MS) and elemental analyses data.


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