alexa An Efficient Synthesis of Biologically Active Tetrachloroquinazolin-2,4-dione | OMICS International | Abstract
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Research Article

An Efficient Synthesis of Biologically Active Tetrachloroquinazolin-2,4-dione

Abstract

Pyrimidine is a prominent member of the diazine family of heterocyclics. Pyrimidine compounds have been explored for use as histamine and adenosine receptor antagonists as well as among several other biological receptors and modulators. The aim of the current research work was to synthesize a new set of tetrachloroquinazolin-2,4-dione derivatives by treatment of N-phenylsulphonyloxytetrachlorophthalimide with some primary aliphatic and aromatic amines via Lossen Rearrangement. The structures of the synthesized compounds were characterized using physical and spectral data such as IR, 1H NMR and mass spectral studies. The newly synthesized compounds were evaluated for their preliminary in vitro antibacterial activity towards Salmonella typhi, Staphylococcus aureus and Bacillus cereus. This study leads us to conclude that quinazolinediones have interesting biological and pharmacological properties towards bacteria.

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