An Efficient Synthesis of Some New Azaspirocycloalkane Derivatives from 1-anilinocycloalkanecarboxamide
- Corresponding Author:
- Mahmoud Abd El Aleem Ali El-Remaily
Department of Organic Chemistry, Faculty of Science
Granada University, Granada, E-18071, Spain
E-mail: [email protected]
Received date: May 16, 2014; Accepted date: May 28, 2014; Published date: June 05, 2014
Citation: Mohamed MAA, Moustafa HM, Ali El-Remaily MAEA (2014) An Efficient Synthesis of Some New Azaspirocycloalkane Derivatives from 1-anilinocycloalkanecarboxamide. Chem Sci J 5:083. doi:10.4172/2150-3494.1000083
Copyright: © 2014 Mohamed MAA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
1-anilinocyclohexanecarboxamides 2a-c were found to be a versatile precursors for the synthesis of five-, six- and seven-membered ring spiroheterocycles compounds 3-14. A general high yielding protocol for the synthesis of many functionalized spiro heterocyclic systems was presented.