alexa An Experimental Study of Decellularized Xenografts Implanted Into the Aortic Position with 4 Months of Follow Up | OMICS International | Abstract
ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
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Research Article

An Experimental Study of Decellularized Xenografts Implanted Into the Aortic Position with 4 Months of Follow Up

P.M. Dohmen1*, F. da Costa2, S. Yoshi3, S.V. Lopes2, F.P. da Souza4, R. Vilani4, O. Bloch5 and W. Konertz1
1Department of Cardiovascular Surgery, Charité Hospital, Medical University Berlin, Berlin, Germany
2Department of Cardiac Surgery, Santa Casa Hospital, Brazil
3Department of Pathology, Pontificia Universidade Catolica do Parana, Curitiba, Brazil
4Department of Veterinary Medicine, Pontificia Universidade Catolica do Parana, Curitiba, Brazil
5AutoTissue GmbH, Berlin, Germany
Corresponding Author : Prof. Dr. P.M. Dohmen
Department of Cardiac Surgery
Heart Center Leipzig, University of Leipzig
Struempellstrasse 39, D-04289 Leipzig, Germany
Tel: +49 341 865 1422
Fax: +49 341 865 1452
E-mail: [email protected]
Received: December 13, 2011; Accepted: January 15, 2012; Published: January 19, 2012
Citation: Dohmen PM, da Costa F, Yoshi , Lopes SV, da Souza FP, et al. (2012) An Experimental Study of Decellularized Xenografts Implanted Into the Aortic Position with 4 Months of Follow Up. J Clinic Experiment Cardiol S4:004. doi:10.4172/2155-9880.S4-004
Copyright: © 2012 Dohmen PM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

This study evaluated decellularized stentless porcine xenografts into the aortic position of seven juvenile sheep. The hemodynamic performance were analyzed by means of echocardiographic examination. Post mortum, specimens were evaluated by gross examination, light microscopy, and immunohistochemical staining. Explantations were performed at up to four months. Echocardiographic evaluation examination showed a maximum flow velocity of 0.94m/s with absence of regurgitation. Gross examination showed smooth and pliable leaflets endothelial cells covered the valve wall and leaflets, deeper layers presented ingrowth of host interstitial cells. There was no evidence for calcification. Our preliminary results showed excellent hemodynamics. Regeneration by host cells and absence of calcifications was observed at 4 months follow-up within the systemic circulation.

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